TOPICAL ANALGESIC ACTIVITY OF CLOVE GEL
Journal Title: Journal of Harmonized Research in Pharmacy - Year 2018, Vol 7, Issue 4
Abstract
Objective: To study the topical analgesic activity of gel containing clove. Methods: The essential oil was extracted from flower bud of Eugenia cryphyllus. Topical gel containing essential oil was inv estigated for analgesic activity in albino rat using hot-plate method. Diclofenac sodium gel was taken as standard drug. Results: The analgesic activity of topical gel preparation was observed in the early phase. The analgesic activity of topical preparation containing 5% Eugenia cryphyllus essential oil showed same analgesic activity compare to standard drug diclofenac sodium (7.833±0.31) at 120 minutes, whereas the test drug showed significant activity (8.166±0.65) than the standard drug (6.5±0.34) at 180 minutes of application of drug by hot-plate method (p<0.001). Conclusion: Hence it may suggest that the essential oil of Eugenia cryphyllus attribute potent analgesic activity. Keywords: Clove gel, in vivo, hot plate method, tail immersion
Authors and Affiliations
Padhan K Dipti
Keywords
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- EP ID EP461514
- DOI 10.30876/JOHR.7.4.2018.84-88
- Views 119
- Downloads 0
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