Toxic And Histopathological Changes of harmful Effect of Diclofenac Sodium on Some Loose Organs in Albino Rats for Twelve Weeks
Journal Title: Journal of Medical Science And clinical Research - Year 2015, Vol 3, Issue 3
Abstract
The present investigation demonstrated the side effect of (I.M.) injection (75 mg/3 ml/ rat/ week) of diclofenac sodium for 12 week on the histological structure of some loose organs of adult rats. During the study no clinical sings were seen and none of the treated animals died during the experiment. This indicates tolerance of the rat to toxicity of the diclofenac sodium. Only histopathological changes were seen after termination and those were in the liver, kidney, heart, pancreas and stomach. These were as follows, vacuolation and degeneration of liver cells, dilated cortical tubules in kidney, degeneration and vacuolation of islet of pancreas, vacuolation of myocardial muscle cells in the heart and erosion and ulceration of the glandular stomach
Authors and Affiliations
Hasan Mohammed
Keywords
Related Articles
- EP ID EP210993
- DOI -
- Views 94
- Downloads 0
Cerebral Venous Sinus Thrombosis-A Study of Clinicoaetiological Profile
Background & Objective: Cerebral venous sinus thrombosis (CVST) remains a diagnostic & therapeutic challenge for the clinician. This study analyses the epidemiological factor, clinical profile, predisposing factor & radi...
MRI Signal Intensity Changes in Cervical Spondylotic Myelopathy and Its Role in Assessing the Surgical Prognosis
Background: The association between MRI signal intensity changes and cervical spondylotic myelopathy (CSM) remains controversial. The objectives of the study were to study different patterns of MRI signal intensity chang...
Effectiveness of Video Assisted Teaching Module on Prevention and Home Management of Diarrheal Diseases among Mothers with under five Children
Quasi experimental design where pre and post with control group approach was used to assess the effectiveness of video assisted teaching module on prevention and home management of diarrhea among 604 mothers of under fiv...
A Clinical Study of Thyroiditis and Its Correlation with TFT, USG, FNAC and Anti TPO Antibodies
Aims and Objectives: To study a population of 50 people in a rural tertiary care hospital with goitre presenting in surgical opd, do a thorough clinical examination, Thyroid function test, ultrasonogram of neck, Fine nee...
Maternal and Neonatal Determinants of Neonatal Jaundice – A Case Control Study
Neonatal jaundice a common condition which affects about 60-80% of newborn and if severe can lead serious neurological sequelae. Determinants include neonatal and maternal factors. A prospective case control descriptive...