Trans-4-aminocrotonic acid (TACA), a potent agonist of GABA(A) and GABA(C) receptors, shows a proconvulsant action in the electroconvulsive threshold test in mice.
Journal Title: Pharmacological Reports - Year 2005, Vol 57, Issue 1
Abstract
In the present study, we evaluated TACA (a potent agonist of GABA(A) and GABA(C) receptors) in the electroconvulsive threshold test in mice. Surprisingly, TACA (at 15 and 25 mg/kg) significantly decreased the threshold. The highest ineffective dose of TACA was estimated as 10 mg/kg. The obtained results indicate that the drug enhancing GABAergic transmission may possess proconvulsant properties in the electroconvulsive test. Such effect was completely opposite to our primary assumption and expectance.
Authors and Affiliations
Kinga Borowicz, Marek Zadrożniak, Stanisław Czuczwar
Keywords
Related Articles
- EP ID EP91031
- DOI -
- Views 109
- Downloads 0
Effect of CYP2C9 and VKORC1 genetic variations on warfarin dose requirements in Indian patients.
Background: Warfarin, an oral anticoagulant is used in patients who are at increased risk of developing blood clots. The management of warfarin therapy is challenging because it shows large inter and intra individual var...
Chronic exercise increases sensitivity to the conditioned rewarding effects of cocaine.
The purpose of this study was to determine whether chronic exercise alters sensitivity to the conditioned rewarding effects of cocaine. Female rats were obtained at weaning and randomly assigned to either sedentary or ex...
Opposite effects of beta amyloid on endothelial cell survival: role of fibroblast growth factor-2 (FGF-2).
Amyloid beta-peptides (Abeta) aggregate during Alzheimer's disease contributing to the development of the pathology. At micromolar concentration Abeta is toxic and accumulates in neurons and in the vasculature. However,...
Involvement of cannabinoid CB(1) receptors in drug addiction: effects of rimonabant on behavioral responses induced by cocaine.
A lot of evidence indicate that endocannabinoids and cannabinoid CB(1) receptors are implicated in drug addiction. In the present study, we investigated the effect of the cannabinoid CB(1) receptor antagonist/partial ago...
Anti-inflammatory and side effects of cyclooxygenase inhibitors.
Nonsteroidal anti-inflammatory drugs (NSAIDs) are the most commonly used drugs in inflammatory diseases, since they are effective in management of pain, fever, redness, edema arising as a consequence of inflammatory medi...