Translational application of DNA methylation biomarkers in malignant tumors
Journal Title: Biomedical Transformation - Year 2021, Vol 2, Issue 3
Abstract
Extensive genetic changes as well as related gene function and activity disorders occur in the de‐ velopment of malignant tumors. DNA methylation in epigenetics is one of the best-characterized epigenetic modi‐ fications. It affects gene expression and genome stability, having an important impact on the development of ma‐ lignant tumors. Most of these epigenetic changes occur in the early stages of malignant tumors and are widespread in the entire malignant tumor. DNA methylation biomarkers are important methods for early tumor diagnosis, prognosis and treatment detection. Cancer-related DNA methylation changes can be detected in blood, feces, urine and other biological samples. It is a non-invasive, rapid and reproducible alternative to tissue biopsy. DNA methyl‐ ation is a simple, economical and highly specific malignant tumor detection method that can be applied to popula‐ tion screening. Although it faces many challenges, DNA methylation biomarkers have unique advantages, having the prospect of clinical translational application and value. This article reviews the characteristics of DNA methyl‐ ation, the mechanism of action as well as the latest research progress in early diagnosis, clinical treatment effects, and prognosis determination in bladder cancer, breast cancer, colorectal cancer and other malignant tumors, dis‐cussing the problems and prospects of clinical translation.
Authors and Affiliations
Liu Jie, Tang Futian, Li Yuming
Keywords
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- EP ID EP767464
- DOI 10.12287/j.issn.2096-8965.20210302
- Views 12
- Downloads 0
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