Treatment of Thyponium Flageliforme in Combination with Curcuma Zedoaria, and Phyllanthus Niruri Synergistically Enhances Apoptotic and Anti-Proliferative Effect on Breast Cancer
Journal Title: Journal of Natural Remedies - Year 2017, Vol 17, Issue 1
Abstract
Introduction: Breast cancer is the most common cancer and the second leading cause of cancer death in women. Combinations of Thyponium flageliforme, Curcuma zedoaria and Phyllanthus niruri (TCP) have been proven as immuno-modulator and retarded tumor progression in vivo. Objective: to investigate the apoptotic and anti-proliferative effect of TCP in C3H mice suffered from adenocarcinoma cells. Methods: 18 mice inoculated with one million cells of breast adenocarcinoma per mouse were assigned into three groups, TCP with dosage 85 and 125 mg were treated for 21 days to evaluate tumor volume, expression of Ki-67 and Capase3. Expression of Ki-67 and Capase3 were measured by immunohistochemistry staining, whilst cancer volume was assessed using calipers. Results: Mann Whitney analysis indicated that tumor volume in TCP groups were lower, otherwise for expression of caspase3, p < 0.05 respectively. Whereas expression of Ki-67 in TCP groups was lower, but not significant, p > 0.05. Conclusion: TCP treatment with 85 and 125 mg dosage capable of reducing tumor volume, increasing caspase3 and lowering Ki-67 expression.
In Vitro Amelioration by Curcumin on Genotoxicity in Workers with Elevated Blood Cadmium Level
Curcumin is a dietary element, easily available and also well-known herb, for its therapeutic uses. On the other hand, cadmium is considered as an omnipresent, hazardous, heavy metal as well as known carcinogen, clastoge...
Randomized, Double-Blind, Placebo-Controlled Phase II Clinical Trial on the Use of <i>Uncaria tomentosa</i> (Cat's Claw) for Aromatase Inhibitor-Induced Arthralgia: A Pilot Study
<strong>Introduction:</strong> Aromatase inhibitors (AI) are widely used in adjuvant breast cancer treatment, and diffuse articular pain secondary to AI use is the most common cause of treatment discontinuation. <em>Unca...
Antioxidant Phenolic Constituents from the Leaves of Acer ginnala var. aidzuense
Acer ginnala Maxim. var. aidzuense (Franch.) Pax was reported recently from Kumamoto Prefecture, Japan after many years. Thus, the main objective of present study was to identify the chemical constituents in the leaves o...
Chemical Composition, Larvicidal and Antibacterial Activity of the Essential Oil of <i>Trachyspermum ammi</i> Fruit
<em>Trachyspermum ammi</em> fruits (<em>T. ammi</em>) are widely sold and used in the Arabian herbal markets, which requires scientific investigations about its biological activities. The GC-MS analysis of the essential...
Treatment of Thyponium Flageliforme in Combination with Curcuma Zedoaria, and Phyllanthus Niruri Synergistically Enhances Apoptotic and Anti-Proliferative Effect on Breast Cancer
Introduction: Breast cancer is the most common cancer and the second leading cause of cancer death in women. Combinations of Thyponium flageliforme, Curcuma zedoaria and Phyllanthus niruri (TCP) have been proven as immun...