Tubular aggregates in systemic lupus erythematosus: A case report and review of literature
Journal Title: Chinese Journal of Nervous and Mental Diseases - Year 2024, Vol 50, Issue 10
Abstract
Tubular aggregates (TA) are ultrastructural abnormalities in muscle biopsies, which can be detected in muscle biopsy specimens from patients with a variety of hereditary and acquired disorders. A 34-year-old male patient diagnosed with systemic lupus erythematosus (SLE) presented with intermittent muscle weakness localized to the proximal extremities of both lower limbs during prolonged oral administration of methylprednisolone, hydroxychloroquine and tacrolimus. Laboratory findings indicated normal creatine kinase levels, and anti-U1-RNP/Sm antibodies were elevated up to 49.45 RU/mL. Electromyography revealed myogenic lesions in the left iliopsoas muscle and muscle pathology demonstrated TA within the muscle fibers. Genetic testing excluded the possibility of hereditary disorders with tubular aggregas. Combined with literature review, the etiology and clinical characteristics of TA were discussed to increase the understanding of the diagnosis of diseases with TA. This case report demonstrates that SLE patients can have fluctuating muscle weakness and TA in muscle pathology. The symptoms of SLE can be partially relieved by adjusting SLE medications.
Authors and Affiliations
Xiaomei LAI, Xiaowei ZHU, Xiaojie ZHANG, Xinghua LUAN, Wenzheng. WANG
Keywords
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- EP ID EP759183
- DOI 10.3969/j.issn.1002-0152.2024.10.013
- Views 45
- Downloads 0
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