Tumor Infiltrating Lymphocytes in Different Stages of Malignant Melanoma and Correlation with Tumor Stage and Other Prognostic Factors: A Retrospective Multicenter Study
Journal Title: Middle East Journal of Cancer - Year 2017, Vol 8, Issue 4
Abstract
Background: Melanoma is one of the most immunogenic tumors that causes a significant immune response. Tumor infiltrating lymphocytes are an important part of this response. Tumor infiltrating lymphocytes are lymphocytes in close association with tumor cells that have infiltrated tumor nests. In this study, we attempt to evaluate the relationship of tumor infiltrating lymphocytes in malignant melanoma with histopathologic findings, tumor stage, and other prognostic factors. Methods: This was a retrospective cross-sectional study. We re-evaluated patients’ specimens and categorized the tumor infiltrating lymphocytes as grades 0, 1, 2, or 3 based on density and distribution of the infiltrating lymphocytes. Results:We enrolled 111 patients with a mean age of 59.33±14.68 years, and a male to female ratio of 1.09. There was no evidence of tumor infiltrating lymphocytes in 17.1% of patients. The melanoma subtypes had the following tumor infiltrating lymphocyte grades: 1 (47.7%), 2 (28.8%), and 3 (6.3%). Cancer stage significantly decreased with increasing grade of tumor infiltrating lymphocyte (P<0.001). Although numerous histopathologic findings had a relationship with tumor infiltrating lymphocytes, only microsatellitosis had a significant relation after adjustments for melanoma stage (P<0.001). Conclusion: Increased density of tumor infiltrating lymphocytes can show a more effective immune response against melanoma. This response can limit cancer progression and result in tumor diagnosis at lower stages of the disease.
Authors and Affiliations
Alireza Ghanadan, Amir Hooshang Ehsani, Ali-Mohammad Farahmand, Mojtaba Mirzaei
Keywords
Related Articles
- EP ID EP299715
- DOI -
- Views 79
- Downloads 0
Recurrent Neuroglycopenia: Do Not Forget Non-islet Cell Induced Tumor Hypoglycemia
Non-islet cell tumor hypoglycemia (NICTH) is an exceedingly rare paraneoplastic condition and often its commonest presenting symptom is hypoglycaemia. Most cases of NICTH are associated with underlying mesenchymal or epi...
Investigation of Programmed Cell Death-1 (PD-1) Gene Variations at Positions PD1.3 and PD1.5 in Iranian Patients with Non-small Cell Lung Cancer
Background: Tumor cells express PD-1 ligands to bind PD-1 on immune cells and escape immune responses. In the present study, we aimed to investigate whether single nucleotide polymorphisms at positions PD1.3 (+7146, rs11...
Coincidence of Anaplastic Lymphoma of the Stomach with Kaposi ’s Sarcoma: A Rare Presentation
Anaplastic large-cell lymphoma is an aggressive non-Hodgkin lymphoma of T cell/null cell origin. It rarely affects the gastrointestinal tract. We present the case of a 58-year-old patient diagnosed with anaplastic lympho...
IL-35 Serum Levels in Bladder Cancer Patients: An Analytical Cross-sectional Study
Background: Bladder cancer is a prevalent disease with significant health care costs and high rates of recurrence. Results from numerous studies to associate bladder cancer with serum biomarkers have been analyzed for pr...
Struma Ovarii Associated with Pseudo-Meigs’ Syndrome: A Rare Presentation of an Infrequent Tumor
Struma ovarii is an uncommon highly specialized ovarian teratoma that accounts for less than 5% of mature teratomas. It is composed predominantly of mature thyroid tissue. Thyroid tissue is observed in 5%-15% of teratoma...