Type 2 diabetes in children and adolescents- A Study of C-peptide and insulin levels
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2017, Vol 5, Issue 3
Abstract
Abstract: Type 2 diabetes mellitus (T2DM) is a disease affecting mostly the adults but is being increasingly recognized in children and adolescents. However, the information about the glycemic profile and insulin resistance is scanty. Therefore, the objective of present study was to study the glycemic profile along with the levels of C-peptide, serum insulin and insulin resistance in children and adolescent withT2DM. 26 patients of either sex (08-18 years age group) suffering from T2DM and 26 normal healthy individuals served as control; were included in the study. In addition to estimation of above mentioned parameters, Homeostasis model assessment for insulin resistance (HOMAIR) were also calculated using standard methods and data from patients and controls were compared by using Student’s t-test. Serum insulin, C-peptide and fasting blood glucose levels were significantly high (p<0.001) in T2DM patients as compared to healthy controls. Marked increase in insulin resistance was also observed in T2DM children and adolescents as characterized by increased HOMAIR index. Therefore, regular monitoring of blood glucose level along with HOMAIR index calculation should be carried even at the early stage of life in order to recognize the incidence of T2DM in children and adolescents. In addition, health information and emphasis on healthy diet along with regular physical exercise may be provided to the children and adolescents in educational programs. Keywords:Insulin resistance, HOMA index, obesity, diabetes mellitus
Authors and Affiliations
Manoj Kumar Nandkeoliar, Rajeev Goyal, Rahul Saxena
Bacteriological Profile and Antibiotic Susceptibility Patterns of Bacteria Isolated From Wound Swab Samples from Patients Attending a Tertiary Care Hospital
Abstract: Wound infections are the most serious cause of mortality and morbidity. Wound infection results whenever there is a breach in skins epithelium exposing subcutaneous tissue making easy way for micro-organisms to...
Venous Thrombosis Revealing Celiac Disease: Two Cases
Celiac disease is an autoimmune enteropathy which can be unusually reveled by venous thrombosis. The association of venous thrombosis and celiac disease has been reported in almost all patients of Maghreb origin. We repo...
Isolation of Anaerobes in Bacterial Vaginosis
Abstract: Anaerobic bacteria causing Bacterial Vaginosis (BV) have been linked to a wide variety of upper genital tract infections, particularly in child bearing age. The aim of the study is to know the prevalence of ana...
Brief Informative Epidemiological Database Mapping on the Outbreak of Ebola Virus in Africa
Abstract: Ebola has become a major medical concern in the last few years in Africa and the year 2014 was called Ebola epidemic year. Even till now, physicians and researchers are not able to find out the effective treatm...
Blood Group Distribution in a Study Population and their Associated Rhesus Factor (Uganda)
Whole blood transfusions have continuously been done in medical hospitals as the major line of emergency recovery on the African continent as a result of limited infrastructure despite of the fact that the general blood...