Ulipristal Acetate- A Selective Progesterone Receptor Modulator
Journal Title: Journal of Contemporary Medicine and Dentistry - Year 2018, Vol 6, Issue 2
Abstract
Background: Unintended pregnancies occur due to unprotected sexual intercourse. To avoid such unplanned pregnancies emergency contraceptives are available. Ulipristal acetate is one such orally active drug which is a selective progesterone receptor modulator. Ulipristal acetate also have promising role in the management of uterine fibroids as it is found that uterine fibroids have progesterone receptors and progesterone activity is responsible for their growth. In this review Ulipristal acetate is reviewed for its action on uterine fibroids and as emergency contraceptive. Methods: Medline database was searched using the keywords like Ulipristal acetate, emergency contraceptives, oral contraceptives, uterine fibroids, menorrhagia to find out the articles related with Ulipristal acetate. Results: The literature indicates that Ulipristal acetate is a good oral emergency contraceptive drug even after 120 hours of unprotected sexual intercourse. Depending upon the menstrual cycle it inhibits ovulation, delays release of ovum, affects ciliar beat frequency and affect endometrial receptivity. It does not have effect on established pregnancy. Ulipristal acetate reduces the uterine fibroid size and also effectively control heavy menstrual bleeding. It does not produce endometrial hyperplasia or any neoplastic changes. Conclusion: Ulipristal acetate is a good emergency contraceptive drug and also useful in the management of uterine fibroids. But still further studies are needed to establish its safety profile.
Authors and Affiliations
Mohammed Shakeel Mohammed Bashir, Kishor A Bansod, Tanveer A Khan
Keywords
Related Articles
- EP ID EP482484
- DOI -
- Views 132
- Downloads 0
Tongue Tie: Successful Management Using Diode Laser
The frenum is a fold of muscle connecting the lips, cheek, or tongue to the jawbone. Ankyloglossia, commonly known as tongue tie, is a congenital anomaly characterized by an abnormally short/tight lingual frenulum leadin...
Catechins- Periodontal Health Booster
The aim of the present study was to evaluate the efficacy of green tea tablet on moderate gingivitis and to measure the tooth stain index following oral intake of the green tea tablet. So a study was conducted among the...
A Clinico–Epidemiological Study of Alopecia Areata in a Tertiary Care Hospital of Telangana
Background: Hair is found only in mammals its primary role was to serve as insulation and protection from unwanted agents. Hair performs no vital functions, whatsoever in man but the psychological functions of hair seem...
Effectiveness of Endonasal Endoscopic Dacryocystorhinostomy for Chronic Dacryocystitis
Background: External Dacryocystorhinostomy was surgical procedure for the treatment of complete nasolacrimal duct obstruction in adults before the endoscopic dacryocystorhinosotomy. This study was done evaluate the rate...
Effectiveness of Pre Procedural Rinse with Chlorhexidine and Povidone-Iodine in Preventing Bio Aerosol Contamination during Ultrasonic Scaling – A Clinical and Microbilogical Study
Aerosol is defined as small droplet usually 5μm or less in diameter, which can remain suspended in air for some time. The aim of the study is to compare the virtue of Chlorhexidine and Povidone-iodine solution as a pre-p...