Use of Rivaroxaban and Apixaban, Two Non-Vitamin K Antagonist Oral Anticoagulants (NOACs), in Renally Impaired Patients - the limits of our knowledge

Journal Title: Journal of Cardiology and Cardiovascular Medicine - Year 2018, Vol 3, Issue 3

Abstract

Patients with chronic kidney disease are at increased risk of thromboembolic complications and are therefore often managed with anticoagulation therapy [1]. While these patients are traditionally treated with Vitamin K antagonists (VKAs), the Non-Vitamin K antagonist oral anticoagulants (NOACs), such as rivaroxaban and apixaban are being used with increasing frequency. Relatively new to the anticoagulant treatment arsenal, both compounds are direct Factor Xa inhibitors and represent an alternative to traditional VKA treatments, such as warfarin. However, because these compounds are at least partially renally eliminated, achieving safe and effective anticoagulation in this vulnerable population has proven to be a challenge [2,3]. With limited published data, there is often uncertainty surrounding which of the NOACs can be safely used.

Authors and Affiliations

KT Moore, L Maria

Keywords

Related Articles

Subacute infectious endocarditis-associated membranoproliferative glomerular nephritis: A Case Report and Review

We experienced a case of membranoproliferative glomerulonephritis (MPGN) caused by subacute infectious endocarditis (SIE). A 57-year-old male farmer complained of fatigue, lack of appetite and gross haematuria for a mont...

Design and validation of an Index to predict the development of Hypertensive Cardiopathy

Introduction: The high morbidity and mortality by hypertensive cardiopathy demand the construction and validation of tools to stratify the risk of developing this condition. Objective: To design and validate an index, b...

A new heart: portraying the physiologic anatomo-functional reconstruction in ischemic cardiomyopathy

Fiber-based model of the left ventricle is known since 1628 but the complex 3D structure of myocardial fibers has not taken into account in normalcy or in disease until the last decade. We here present the case of a 60-y...

Is there an ideal blood pressure during cardiopulmonary bypass to prevent postoperative cerebral injury? – What does the recent evidence say?

Post cardiac surgery stroke is a devastating complication with an incidence as high as 50%1. The association between intra-operative mean arterial blood pressure (MAP- better called linear blood pressure) during cardiopu...

Hyperkalemia: An archenemy in emergency medicine. Description of two case reports

Potassium is an important ion capable to maintain intra-extracellular electric gradient. Variations in the intra-extracellular ionic flow may alter cells functions, skeletal and smooth muscle contractility and electric a...

Download PDF file
  • EP ID EP537795
  • DOI 10.29328/journal.jccm.1001026
  • Views 113
  • Downloads 0

How To Cite

KT Moore, L Maria (2018). Use of Rivaroxaban and Apixaban, Two Non-Vitamin K Antagonist Oral Anticoagulants (NOACs), in Renally Impaired Patients - the limits of our knowledge. Journal of Cardiology and Cardiovascular Medicine, 3(3), 49-51. https://www.europub.co.uk/articles/-A-537795