USE POLYVINYLPYRROLIDONE IN TECHNOLOGY OF GYNAECOLOGICAL POWDERS CONTAINING LACTIC ACID COMPLEXED WITH CHITOSAN
Journal Title: Progress on Chemistry and Application of Chitin and its Derivatives - Year 2014, Vol 0, Issue
Abstract
Gels obtained from powders containing lactic acid complexed with chitosan reveal a stoichiometric ratio of 1:1, 2:1, 3:1, 4:1 and 8:1. Their pH ranged from 3.92 to 4.44 for 1:1 gels and from 2.36 to 2.84 for the 8:1 ratio. The addition of 5% polyvinylpyrrolidone K-90 increased the pH from 4.28 to 4.52 for 1:1 and from 2.58 to 3.30 for the 8:1 ratio. The addition of 5% polyvinylpyrrolidone K-90 increased the dynamic viscosity from 84 to 510 mPa.s for 1:1 gels and from 47 to 386 mPa.s for the 8:1 ratio. The gels obtained from powders possess the work of adhesion - the energy needed to separate the gel from the probe was 15.2 g/s for gels with 5% polyvinylpyrrolidone K-15, 52.76 g/s for gels with 5% polyvinylpyrrolidone K-30, and 56.6 g/s for gels containing 5% polyvinylpyrrolidone K-90. The results proved that it is possible to produce a preparation with optimal pharmaceutical and application properties.
Authors and Affiliations
Katarzyna Małolepsza-Jarmołowska
Keywords
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- EP ID EP73406
- DOI 10.15259/PCACD.19.12
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