Vaptans
Journal Title: BMH Medical Journal - Year 2015, Vol 2, Issue 4
Abstract
There are three receptors for vasopressin (Antidiuretic Hormone) - the V1a, V1b, and V2 receptors. The V2 receptors primarily mediate the antidiuretic response, while V1a and V1b receptors primarily cause vasoconstriction and adrenocorticotropic hormone (ACTH) release, respectively. V2 receptor antagonists, collectively known as Vaptans, competitively block the binding of vasopressin to V2 receptors, which are located on renal collecting duct cells. This prevents Vasopressin-mediated activation of these receptors. These class of agents cause selective water diuresis (aquaresis), and does not cause sodium and potassium loss. These agents by causing aquaresis, helps to raise serum sodium levels.
Authors and Affiliations
Raju A Gopal
Keywords
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