Have we become overly reliant on lipid rafts? Talking Point on the involvement of lipid rafts in T-cell activation

During the past decade, the lipid-raft hypothesis has focused attention on the role of membrane domains in controlling cellular functions. Among the best-studied roles of lipid rafts is the regulation of T-cell signallin...

Atypical ubiquitin chains: new molecular signals. ‘Protein Modifications: Beyond the Usual Suspects' Review Series

Ubiquitin (Ub) is a small protein modifier that regulates many biological processes, including gene transcription, cell-cycle progression, DNA repair, apoptosis, virus budding and receptor endocytosis. Ub can be conjugat...

A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells

The embryonic programme ‘epithelial–mesenchymal transition' (EMT) is thought to promote malignant tumour progression. The transcriptional repressor zinc-finger E-box binding homeobox 1 (ZEB1) is a crucial...

Scientific discourse 2.0. Will your next poster session be in Second Life ®?

GM directive deficiencies in the European Union. The current framework for regulating GM crops in the EU weakens the precautionary principle as a policy tool