VIRTUAL TOXICITY STUDIES OF NOVEL 1,4-DIHYDROPYRIDINE DERIVATIVES 

Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2013, Vol 4, Issue 3

Abstract

Virtual toxicity of N3, N5-diphenyl-1,4-dihydropyridine-3,5-dicarbohydrazides [2A-2D’] and 2,6-dimethyl-1,4-dihydropyridine-3,5-yl-bis[carbonyl-2-(phenyl)]pyrazolidine-3,5-diones] [3A-3D’] were extensively studied. Computational toxicology and mutagenicity profiles of these compounds were generated by using TOPKAT 6.1 (Toxicity Prediction Komputer Assisted Technology version 6.1). The molecular structure of the query compound was given as a SMILES string and a desired TOPKAT predictor was selected. TOPKAT automatically conducts a unique 2-stage analysis of the query compound. Various models were assessed and obtained results were thoroughly discussed. 

Authors and Affiliations

Asma samaunnisa , C. H. S. Venkataramana, V Madhava

Keywords

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  • EP ID EP161719
  • DOI 10.7897/2230-8407.04354
  • Views 110
  • Downloads 0

How To Cite

Asma samaunnisa, C. H. S. Venkataramana, V Madhava (2013). VIRTUAL TOXICITY STUDIES OF NOVEL 1,4-DIHYDROPYRIDINE DERIVATIVES . International Research Journal of Pharmacy (IRJP), 4(3), 249-253. https://www.europub.co.uk/articles/-A-161719