Viscosupplementation in Osteoarthritis of Knee
Journal Title: International Journal of Interdisciplinary and Multidisciplinary Studies (IJIMS) - Year 2015, Vol 2, Issue 10
Abstract
Osteoarthritis (OA) is a complex joint disease and is caused by inflammatory mediators, along with a process of “wear and tear of cartilage”. Osteoarthritis results in cartilage degradation, synovial inflammation, subchondral bone eburnation, degeneration of menisci, and capsular hypertrophy, which takes part in the pathogenesis of OA. Pain is the predominant symptom of OA. However the exact mechanism causing pain is multifactorial and is still not well known. Viscosupplementation with intraarticular hylauronic acid (HA) promotes chondrocyte hyaluronic acid synthesis and prevents the further cartilage degradation and may possible help to promote the cartilage regeneration. It is also postulated to reduce the production of inflammatory mediators and matrix metalloproteinase involved in OA. Viscosupplementation reduces osteoarthritis symptoms in early to moderate OA, and improves functional outcome, if other conservative treatment modalities are ineffective. Viscosupplementation might delay the need for knee replacement surgery. Prospective study was conducted to know the efficacy of Viscosupplementation with hyaluronic acid (HA) in patients with osteoarthritis knee joint.1200 patients meeting the inclusion and exclusion criteria with OA knee were included in the study. The patients were categorised based on radiological classification of Kellgren and Lawrence . Parameters includesVisual Analogue Scale (VAS) while performing activity of daily living modified the Western Ontario and McMaster Universities Osteoarthritis (WOMAC) index. We found that there is significant improvement in pain and functional outcome at 6 months of follow up. Here We came to a conclusion that intraarticular hylauronic acid injection is potentially a effective treatment for osteoarthritis of knees in multiple doses and is adjunct treatment to oral analgesics to decrease the pain and its doses. It helps in improving the function in early osteoarthritis knee joint and might delay the need for future knee surgery.
Authors and Affiliations
Sunil Nikose, Mahendra Gudhe , Pradeep Singh , Mridul Arora
Keywords
Related Articles
- EP ID EP30989
- DOI -
- Views 285
- Downloads 0
Trend of Social Recruitment in India in 21st Century
This study will try to gauge the acceptance and use of social networking by recruiters and professionals in 21st century India. Social Recruitment started from USA which is home country for almost every (early) social...
Economic Rights of Women in Islam: Some Reflections
Many motivated misconceptions about Islam have been perverted and given currency in modern times. One of these relates to the position of women in Islam. It is affirmed from the rooftops that Islam does not admit equali...
Role of Vernacular newspapers in Odisha’s struggle for independent state province
Media is one of the best platform to inform, aware and motivate the people at large. It helps to create mass consensus in bringing out socio-cultural and political change in society. There are ample instances around the...
Strategic Alignment of Personal and Organizational Vision and Values: A Vedic Perspective
This paper focuses on the alignment of personal with organization vision and values, taking a Vedic perspective, which is a strategic perspective for suitable organizational development. This perspective enables us to d...
State of Water Governance in Dhaka Metropolitan City of Bangladesh: Evidence from Three Selected Slums
Improvement of water management and services remains as a key challenge towards ensuring sustainable governance system presently. It is beyond belief that water rich countries like Bangladesh have to face water crisis n...