Vitality of Pro-Inflammatory Cytokine, Scavenger Receptor Proteins and Atherosclerotic Plaque Markers in Risk Prediction of Diabetic Nephropathy
Journal Title: International Journal of Current Microbiology and Applied Sciences (IJCMAS) - Year 2017, Vol 6, Issue 1
Abstract
About 10 to 40 % Type 2 diabetes (T2DM) and 30 % Type 1 diabetes (T1DM) suffer from kidney failure, increases huge financial burden for care. Patients with uncontrolled diabetes prone to ESRD, require kidney transplantation, haemodialysis or peritoneal dialysis which adds psychological distress. Present research work. It is prospective study includes 241 subjects conducted at the Department of Biochemistry, D Y Patil University, Navi Mumbai, India. Early detection of Kidney injury evaluated by IL-6, IL-10 CD36 and LDLr gene expressions in T2DM with microalbuminuria by rt-PCR and biochemical parameters by spectrophotometry methods. In study groups all renal parameters and lipids are within normal range except albumin/creatinine ratio (p<.012), e-GFR (p<.00) and cholesterol (p<.00). Descriptive and post hoc test analysis showed high significance (p<.00) for IL-6, IL-10, CD36 and LDLr. Screening biochemical renal parameters are not enough to prevent DN even in microalbuminuria. Early detection of gene expressions of IL-6, IL-10 and CD36, LDLr predict forthcoming risk of kidney injury. Early intervention may prevent morbidity of kidney in type II diabetes associated diabetic nephropathy.
Authors and Affiliations
V. Khot, K. S. Yadav, V. A. Haldankar, A. K. BHUTEY
Keywords
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- EP ID EP567168
- DOI 10.20546/ijcmas.2017.601.015
- Views 91
- Downloads 0
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