Vitamin B12 deficiency, its prevalence and haematological manifestations - A study in a tertiary care hospital
Journal Title: Indian Journal of Pathology and Oncology - Year 2018, Vol 5, Issue 2
Abstract
Aim To determine the prevalence of vitamin B12 deficiency in subjects with anaemia and elevated mean corpuscular volumeMaterials and Methods Blood samples from 119 subjects were selected for the study based on the inclusion and exclusion criteria laid down Blood samples were analysed on sysmex KX 21 haematology analyser Morphological evaluation of blood cells was done on peripheral blood smear Serum vitamin B 12 assays were done Qualitative and quantitative variables were analysed by statistical methodsResults Out of 119 subjects taken for study 70 588 were male and 49 412 were female with mean age plusmn SD 405plusmn 18 Vitamin B 12 deficiency was noted in 82 69 of which 12 101 were in Borderline levels of deficiency 31 261 were in deficient levels and 39 328 were in severely deficient group Red blood cell indices were categorized as per different groups of vitamin B 12 levels Pancytopenia was noted in 671 54 of B 12 deficient individuals Significant negative correlation was found between vitamin B 12 levels and mean corpuscular volume r 0215 p 0019 A positive correlation was found between vitamin B12 and platelet count p lt 0001 and also with leukocyte counts p value lt 0001 These correlations were found to be statistically significant Peripheral blood film examination shows macrocytosis in 76 64 smears and hypersegmented neutrophils in 66 56 smearsKeywords Vitamin B 12 deficiency prevalence Megaloblastic anaemia Pancytopenia Mean corpuscular volume
Authors and Affiliations
Jenita Christiana Samson, Umamaheswari Karuppanan, Hemalatha Ganesan, Sudha Velusamy, Priya Thangara
Keywords
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- EP ID EP475492
- DOI 10.18231/2394-6792.2018.0043
- Views 77
- Downloads 0
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