Weight Management Effects of a Mixture of Conjugated Linoleic Acid and L-Carnitine in Diet Induced Obese Rats
Journal Title: Journal of Advances in Medicine and Medical Research - Year 2016, Vol 12, Issue 1
Abstract
Aims: To examine simultaneous effects of Conjugated Linoleic Acid (CLA) and L-carnitine (LC) on weight gain in diet induced obese rats. Study Design: Experimental study. Place and Duration of Study: Department of Nutrition, Faculty of Para-Medical Sciences, Ahvaz Jundishapur University of Medical Sciences (January 2014 to January 2015). Methodology: Forty male Wistar rats were randomly divided into two groups: Normal fat diet (n=8), and High fat diet (HFD) (n=32). After eight weeks, the second group maintained HFD and was subdivided into 4 categories: Corn Oil group, 500 mg CLA, 200 mg LC, and 500 mg CLA+ 200 mg LC (all doses per kg body weight), which were administered by oral gavage for four weeks. Body weights were measured and recorded weekly by means of a digital scale. SPSS Version 16 was used for statistical analysis. Results: At the end of eighth week, a significant difference in weights was observed between HFD (295.43±5.36 gr) and NFD (246.38±6.48 gr) group. After four weeks, LC significantly reduced weight gain by 7.5% (P = .047). Trend of weight gain in CLA and LC + CLA groups were decelerated (24 and 25 gr respectively), but it was statistically insignificant (P = .08, .12 respectively). Conclusion: Findings of this experimental study showed that a high fat diet led to obesity and combined LC and CLA could decelerate weight gain to some extent. However, it needs further work to validate reliability in human.
Authors and Affiliations
Maryam Nazari, Majid Karandish, Mohammad-Taha Jalali, Ali-Hossein Saberi
Keywords
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- EP ID EP340030
- DOI 10.9734/BJMMR/2016/21609
- Views 89
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