Why OSA may be Regarded as the Real Hidden Killer in Diabetes
Journal Title: Journal of Endocrinology and Diabetes - Year 2014, Vol 1, Issue 1
Abstract
Obstructive Sleep Apnea Syndrome (OSAS) is a common and usually overlooked phenomenon causing a deep reduction in oxygen delivery to the body tissues and a serious disruption of the sleep pattern. Furthermore there are scattered reports in the medical literature pointing to a role of this respiratory disturbance on sudden death. We hypothesize that the phenomenon may have a role in the vascular damage and the high cardiovascular death rate of diabetes interacting at least at three consecutive steps.
Authors and Affiliations
Patrizio Tatti, Strollo F, Politi L, Passali D
Diabetes Autoantibodies Mediate Neural- and Endothelial Cell- Inhibitory Effects Via 5-Hydroxytryptamine- 2 Receptor Coupled to Phospholipase C/Inositol Triphosphate/Ca2+ Pathway
Aims: To identify the G-protein coupled receptor(s) on neuroblastoma and endothelial cells which mediate neural- and endothelial cellinhibitory effects in plasma autoantibodies from a subset of older type 2 diabetes with...
Non-classical Congenital Adrenal Hyperplasia: the challenge of an accurate diagnosis
We present the case of a 24 year-old lady with mild congenital adrenal hyperplasia (CAH) who presented with infertility, hirsutism and clitoromeglay and increased 17 alpha hydroxy progesterone serum levels. She was treat...
No Effect of Aprotinin (Trasylolâ„¢) on Degradation of Exogenous and Endogenous Glucagon in Human, Mouse and Rat Plasma
Traditionally, aprotinin (Trasylolâ„¢) has been added to plasma samples prior to glucagon analysis. However, the evidence for the need of aprotinin is sparse and based on results obtained when radioimmunoassay (RIA) techni...
Gut Microbiota-Induced 5-HT Synthesis and Obesity
Although the role of gut microbiota in type 2 diabetes and the therapeutic effects of metformin have recently been reported [1- 3], the intestinal microbiota composition may be also influenced by obesity. Microbiota depl...
Circulating Lipocalin-2 Levels Are Associated With Soluble Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 Levels In Type 2 Diabetic Patients
Purpose: Diabetes mellitus is associated with atherosclerotic and cardiovascular diseases. Our aim was to investigate the levels of lipocalin-2 (LCN-2) and soluble Lectin-like oxidized low-density lipoprotein receptor-1(...