Why study proteome of red blood cells stored in blood banks
Journal Title: Postępy Nauk Medycznych - Year 2012, Vol 25, Issue 7
Abstract
The primary goal of any blood bank is to prepare red blood cells (RBCs) being able to efficiently deliver oxygen to the tissue and survive in the recipient circulation long enough to perform its functions. Discovery of blood anticoagulant and modern preservation solutions enabled to store the RBCs for 42 days. Transfusion medicine is characterized by very restrictive control system, which in order to be constantly improving, needs better understanding of RBC senescence processes undergoing during storage. The necessity of this analysis is supported by many clinicians, mostly from the cardiology departments, who point out different recoveries depending on the storage period and presence of leukocytes in the blood the patient received. However, till now the molecular bases of RBC senescence and its influence on transfusion efficiency are still not well defined. Proteomic analysis with accompany of modern mass spectrometry techniques reveals not only unexpected complexity of RBC proteome but also serves as a future tool to assess the changes that RBCs undergo during storage. This can be of immense help for further improvement of red blood cells preparation and storage methods, thereby increasing the quality and safety of transfusions.
Authors and Affiliations
Adrianna Łoniewska-Lwowska, Jadwiga Fabijańska-Mitek, Katarzyna Koza
Keywords
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