Abstract

Objective: To calculate the effect of methanolic extract of Curculigo orchioides (C. orchioides) on rate of wound contraction and estimation of various biochemical parameters such as superoxide dismutase, lipid peroxidation and nitric oxide levels in the granulation tissue of diabetic and non-diabetic mice. Methods: The methanolic extract of C. orchioides with the concentration of 200 mg/kg and 400 mg/kg body weight was induced through intraperitoneal injections in diabetic and non-diabetic mice. The results were compared with control and metformin induced diabetic and non-diabetic mice. Results: The results showed that root tubers of C. orchioides were a potent source of antioxidative phenolic compounds that counteract with reactive oxygen species responsible for delayed wound healing. The root tubers of C. orchioides significantly increased the level of superoxide dismutase, nitric oxide and decreased lipid peroxidation in granuloma tissue of diabetic mice. Conclusions: The extract of root tubers of C. orchioides increases the rate of angiogenesis and improves antioxidant enzymes status that eventually leads to faster wound healing in diabetic condition. However, further studies are needed to explore the molecules present in C. orchioides that lead to faster wound healing.

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