Zaburzenia procesu O-GlcNAcylacji w nowotworach
Journal Title: Folia Medica Lodziensia - Year 2014, Vol 41, Issue 1
Abstract
O-GlcNAcylation is a post-translational modification involving the addition of a N-acetylglucosamine moiety to the serine/threonine residues of cytosolic or nuclear proteins. Two enzymes are responsible for cyclic O-GlcNAcylation: O-GlcNAc transferase (OGT) which catalyzes the addition of the GlcNAc moiety from UDP-GlcNAc to target proteins and O-GlcNAcase (OGA) which catalyses the hydrolytic removal of the sugar moiety from proteins. Dynamic and reversible O-GlcNAcylation is emerging as an important regulator of diverse cellular processes, such as signal transduction, metabolism, transcription, translation, proteasomal degradation and cell cycle. O-GlcNAcylation occurs on serine or threonine residues of proteins at sites that may also be phosphorylated. Therefore, an extensive crosstalk exists between phosphorylation and O GlcNAcylation. Recent studies indicate that increased O-GlcNAcylation is a general feature of cancer. Elevated O-GlcNAcylation (hyper-O-GlcNAcylation) occurs in many human malignancies including solid tumors such as lung, prostate, breast, colorectal, liver, pancreatic cancers as well as non solid cancers such as chronic lymphocytic leukemia. The changes in O GlcNAcylation are associated with the changes in OGT and OGA expression levels. Hyper-O-GlcNAcylation may be linked to the various hallmarks of cancer, including cancer cell proliferation, survival, invasion, metastasis and metabolism. This paper reviews recent findings related to O GlcNAc-dependent regulation of signaling pathways, cell cycle, transcription factors, and metabolic enzymes in cancer cells.
Authors and Affiliations
Piotr Ciesielski, Anna Krześlak
Keywords
Related Articles
- EP ID EP169353
- DOI -
- Views 105
- Downloads 0
Czy „cichy” polimorfizm pojedynczego nukleotydu (SNP) C1236T genu ABCB1 jest związany z predyspozycją do rozwoju depresji i skutecznością jej leczenia? - badanie wstępne
Introduction: According to the World Health Organization about 350 million people around the world are affected by depression. Despite the high prevalence of this disease the mechanism of depression origination as well a...
Ocena jakości snu w odniesieniu do stężenia serotoniny i melatoniny w surowicy u osób z marskością wątroby
Sleep disorders occur in people who suffer from liver cirrhosis, this usually involves a change in the rhythm of melatonin secretion and its metabolism. Delayed sleep phase syndrome does not always correlate with the deg...
Rola mesalazyny w chemoprewencji raka jelita grubego
Colorectal cancer (CRC) is the fourth most commonly diagnosed cancer in females and the third in males. Every year there are more than a million new cases of colorectal cancer and more than six hundred thousand patients...
Wyniki leczenia operacyjnego raka nerki w I Klinice Urologii Uniwersytetu Medycznego w Łodzi w latach 2004–2010
Introduction. Aim of the study: The only effective treatment method for all forms of the kidney cancer is surgery with possible subsequent institution of neoadjuvant treatment. The standard management involves nephrectom...
Rola tryptofanu i serotoniny w patogenezie i leczeniu zespołu jelita nadwrażliwego
Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder of a very complex etiopathogenesis. There are three clinical types of this syndrome: with constipation, with diarrhea and mixed, with alternating c...