Zastosowanie szczepionek w prewencji HPV-zależnych raków głowy i szyi oraz brodawczaków krtani
Journal Title: Otolaryngologia Polska - Year 2014, Vol 68, Issue 4
Abstract
Recent data demonstrate that human papilloma virus (HPV) plays a role in pathologies other than ano-genital cancers, specifically head and neck malignancies, and non-cancerous conditions such as recurrent respiratory papillomatosis (RRP). High-risk HPV16 and 18, and low risk HPV6 and 11 play the main role in HPV-related pathologies. As more and more information about the role of HPV infection in non-cervical diseases is amassed, additional questions about whether prophylactic HPV vaccines will effectively prevent these conditions are raised. HPV vaccination programs for the cervical pathology are being implemented worldwide. In the United States, the US Food and Drug Administration (FDA) approved the qua drivalent HPV vaccine for girls in 2006 and for boys in 2011. These vaccination programs were aimed at the genital, HPV-related lesions, and there was not much recognition at that time of how HPV vaccination programs might affect oral HPV infection, which is a risk factor for the development of HPV-related head and neck cancers. Vaccination has proved to be a successful policy, and an extant recommendation is aimed at preventing HPV and associated cervical and other anogenital cancers with the routine use of HPV vaccines for males and females. However, HPV vaccines are presently not recommended for preventing oropharyngeal cancer (OPC), although they have been shown to be highly effective against the HPV strains that are most commonly found in the oropharynx. This review is aimed at presenting the evidence-based knowledge concerning HPV vaccination and highlighting the trials and strategies for vaccine administration in HPV-dependent head and neck pathologies.
Authors and Affiliations
Małgorzata Wierzbicka, Agata Józefiak, Joanna Jackowska, Jarosław Szydłowski, Anna Goździcka-Józefiak
Keywords
Related Articles
- EP ID EP52524
- DOI -
- Views 115
- Downloads 0
Late phoniatric results of treatment of patients with cleft palate operated on by one surgeon
Introduction. The aim of the study was the assessment of the late speech results the cleft palate patients. Material and methodic. From January 1987 to December 1996 the first author performed 268 cleft palate surgeries....
Problematyka cukrzycy u chorych z nowotworami głowy i szyi leczonych operacyjnie
The aim of study was to assess the course of treatment and final hospital costs of head and neck cancer patients with diabetes mellitus in comparison with control group of cancer but non-diabetic patients. Material and m...
Leiomyosarcoma of the external ear – Case report
In head and neck region leiomyosarcoma is a very rare finding. This tumor is usually located in abdominal cavity. We report a case of 78-year-old man with tumor of the auricle that was resected with 0.7 cm margin. Histol...
Odległe wyniki i analiza przyczyn niepowodzeń u chorych na raka krtani napromienianych konwencjonalnie i schematem przyspieszonego frakcjonowania w latach 1995– 1998
The clinical material consists of 217 patients with squamous cell carcinoma in supraglottic and glottic larynx in clinical stage T1– 3N0M0 irradiated radi cally in Warsaw Oncology Centre in 1995–1998. All patients were t...
The new insight into the pathogenic unity of the upper and lower airways
Between the upper and the lower respiratory tracts exists a link. Numerous epidemiological, immunological studies and clinical observations suggest the pathogenic unity of the upper and lower airways. The most important...