A case report on succinylcholine hypersensitivity presenting as severe bronchospasm
Journal Title: Indian Journal of Pharmacy and Pharmacology - Year 2019, Vol 5, Issue 4
Abstract
Succinylcholine is a depolarizing neuromuscular blocking agent useful as an adjunct to general anaesthesia Hypersensitivity to succinylcholine might lead to flushing skin rash bronchospasm and shock However incidence of bronchospasm is less common in man A 26 years old female patient at our setup while undergoing dilatation and evacuation procedure was administered with Injection Scoline Succinylcholine 50 milligrams intravenous Within a minute patient was gasping and underwent severe bronchospasms Her SpO2 was 94 along with development of crepitation with tachypnoea and spasms 30 respirationsminute She was immediately resuscitated and intubated by the attending anaesthetist treated for bronchospasm as well as shifted on ventilator Within few hours she was taken off the ventilator and extubated She was stable then and discharged after two days Hypersensitivity to NMBAs low incidence of 1 in 6000 20000 NMBAs have a direct effect on mast cells thereby causing hypersensitivity reactions Succinylcholine is considered to have 1 histamine releasing activity of tubocurarine producing serious hypersensitivity reactions This histamine released acts on the effector endreceptors in bronchial wall leading to bronchoconstriction and sometimes a fullblown spasm If timely management failed it can result into an anaesthetic disaster Rechallenge with succinylcholine was avoided due to possibility of fatal consequences According to WHO UMC criteria Naranjo Scale for causality assessment causality was termed as ProbableKeywords Bronchospasm Hypersensitivity Lifethreatening Neuromuscular Blocking Agent NMBA Suspected adverse drug reaction
Authors and Affiliations
Sapna D. Gupta, Haiya J Sheth, Supriya D. Malhotra, Pankaj R. Patel
Keywords
Related Articles
- EP ID EP478576
- DOI 10.18231/2393-9087.2018.0044
- Views 100
- Downloads 0
Prescription pattern and adverse drug reaction profile of drugs prescribed in dermatology out-patient department at a tertiary care teaching hospital
Introduction: Skin diseases are chronic in nature and they require lifetime treatment. Prescription pattern reflects health professional attitude towards the disease and role of drugs in its treatment. The study of presc...
The observational study of various pharmacy services, its organizational structure, planning considerations and managerial issues in Hospital Pharmacy in a Medical College in Punjab, India
Introduction: The pharmacy is one of the most extensively used therapeutic services of the hospital. The study was conducted to assess and analyze the type of hospital pharmacy services and drug distribution system; the...
Knowledge, attitude & perceptions of 3rd term medical students towards clinical trials in a medical college in southern India
Aim of the study: The present Study was performed to know the awareness of clinical trials and to assess the effectiveness of an educational intervention. Materials and Method: This was a questionnaire-based pre- and pos...
Prescription pattern and adverse drug reaction profile of drugs prescribed with focus on NSAIDs for orthopedic indications at a tertiary care hospital
Introduction: The Non-steroidal Anti-inflammatory Drugs (NSAIDs) constitute the largest group of drugs used worldwide for indications like rheumatoid arthritis, osteoarthritis, low back pain etc. Periodic evaluation of d...
Self-medication practices among residents of Puducherry – A cross sectional questionnaire based survey
Introduction: Improper self-medication of Over the Counter (OTC) drugs and /or drugs from earlier prescription may result in adverse drug reactions and /or serious drug interactions with co-administered alternate system...