A Computational Model of Electrophysiological Properties of Cardiomyocytes
Journal Title: Вісник НТУУ КПІ. Серія Радіотехніка, Радіоапаратобудування - Year 2018, Vol 0, Issue 72
Abstract
Introduction. The method of electrical analogies for the analysis of bioelectric dynamic processes in cardiomyocytes is used in the study. This method allows for replacing investigation of phenomena in non-electrical systems by research of analogous phenomena in electrical circuits. The investigation of time processes in cardiac cells is based on the solution of the system of ordinary differential equations for an electrical circuit. Electrophysiological properties of cardiomyocytes such as refractory period, maximum capture rate and electrical restitution are studied. Mathematical modeling. Computational simulation of the action potential and currents for $K^+$, $Na^+$, $Ca^{2+}$ ions in cardiomyocytes is performed by using the parallel conductance model. This model is based on the assumption of the presence of independent ion channels for $K^+$, $Na^+$, $Ca^{2+}$ ions, as well as leakage through the membrane of cardiac cell. Each branch of the electrical circuit reflects the contribution of one type of ions to total membrane current. Results. The obtained electrical restitution curves for ventricular and atrial cardiomyocytes are presented in the paper. The proposed model makes it possible to identify the areas with the maximum slope on the restitution curves, which are crucial in the development of cardiac arrhythmias. Dependences of calcium current on stimulation frequency for atrial and ventricular cardiomyocytes are obtained. Analysis of the kinetics of calcium ions under various protocols of external influences can be useful for predicting the contractile force of cardiomyocytes. Conclusion. The results of calculations can be used to interpret the experimental results obtained in investigations of cardiomyocytes using the "laboratory on a chip" technology, as well as in the design of new experiments with cardiomyocytes for drug screening, cell therapy and personalized studies of heart diseases.
Authors and Affiliations
N. Ivanushkina, E. Ivan'ko, Yu. Prokopenko, A. Redaelli, V. Tymofieiev, R. Visone
Keywords
Related Articles
- EP ID EP308177
- DOI 10.20535/RADAP.2018.72.69-77
- Views 93
- Downloads 0
Calculating technique of the codegram length for asymptotically reliable radio lines of control
Introduction. Actuality of the task of a choice of codegram length for high-reliable radio lines of control is justified. A purpose and tasks of article are defined. Receiving of estimated ratios. Check of calculation ac...
Algorithm of uniting of optimal one-dimensional filtering outcomes for image processing
The nonlinear algorithm of uniting of one-dimensional optimal filtering outcomes which describes the form of a posteriori probability density of image pixel is synthesized. Linear algorithm of uniting is obtained for the...
Method of object ranging by signaling security means based on measurement of electrical capacity of sensing element
Introduction. Analysis of the researches in the field of signaling break-away protection means allowed to determine scientific and technical solutions which solve tasks concerning realization of object ranging. However,...
Taking into account the uncoordinated load when researching the structure of electromagnetic field in the microstrip using the method of ferromagnetic resonance (FMR)
The results of analysis of the causes of sizable discrepancy of data for longitudinal constituent H z obtained experimentally and numerically with the help of Microwave Studio program are given. The author also examined...
Radar-eddy current GPR
Introduction. At present there are many electrical schematic metal detectors (the most common kind of ground penetrating radar), which are differ in purpose. Each scheme has its own advantages and disadvantages compared...