A PRELIMINARY STUDY ON THE EFFECTS OF PETROLEUM ETHER & ALCOHOLIC BARK EXTRACT OF Anthocephalus cadamba (Roxb.) MIQ. IN ACUTE AND CHRONIC IN-VIVO INFLAMMATORY RAT MODELS
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 2
Abstract
In order to appraise the traditional use of Anthocephalus cadamba, the petroleum and alcoholic extracts of stem bark of Anthocephalus cadamba, were investigated for their acute and chronic anti-inflammatory activity. The anti-inflammatory activity of petroleum ether and alcoholic extract were evaluated using the Carrageenan induced paw oedema (acute inflammation) and Cotton pellet induced granuloma (chronic inflammation) in rats. In the carrageenan induced rat paw edema model, both the extracts were found to exhibit significant reduction in paw size. The groups treated with alcoholic extract at the dose 667 mg/kg showed maximum effect at 4th hour and the group treated with petroleum ether extract at the dose of 286 mg/kg has shown the maximum effect in 4th hour of carrageenan administration. In cotton pellet granuloma the group treated with petroleum ether extract at the dose of 286 mg/kg suppressed the transudative, exudative and proliferative phases of chronic inflammation. The anti-inflammatory effect produced by both petroleum ether and alcoholic extract at the dose of 667 mg/kg, 286 mg/kg, and 200 mg/kg was compared with the reference drug diclofenac sodium. Over the study period there was no mortality or toxic signs & symptoms recorded in the group of mice given 2000 mg/kg p.o of petroleum ether, alcoholic extract. The results demonstrate that though both the extracts are equally effective in acute inflammatory condition but petroleum ether extract of stem bark of Anthocephalus cadamba has showed more significant anti-inflammatory activity in chronic inflammatory condition than alcoholic extract.
Authors and Affiliations
Poonam Nagar , Kalayani Diwakar , Ashish Nagar , Sumeet Gullaiya , Vishal Dubey , Varun Singh
Keywords
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