A review on recent innovation in osmotically controlled drug delivery system
Journal Title: Indian Journal of Pharmaceutical and Biological Research - Year 2014, Vol 2, Issue 2
Abstract
In recent years, oral controlled release (CR) system is most acceptable dosage form by the patients. Drugs having short biological half-life and poor water solubility are the suitable candidate for development of CR system. They include dosage forms for oral and transdermal administration as well as injectable and implantable systems. For most of drugs, oral route remains as the most acceptable route of administration. Certain molecules may have low oral bioavailability because of solubility or permeability limitations. Development of an extended release dosage form also requires reasonable absorption throughout the gastro-intestinal tract (GIT). Among the available techniques to improve the bioavailability of these drugs fabrication of osmotic drug delivery system is the most appropriate one. The release of drug(s) from osmotic systems follows zero order. It is mainly governed by various formulation factors such as solubility and osmotic pressure of the core component(s), size of the delivery orifice, and nature of the rate-controlling membrane. The present review highlights an overview of OCDDS. And new technologies, fabrication and recent clinical research in osmotic drug delivery. Further, the challenges of these technologies and its future perspective are also discussed at length.
Authors and Affiliations
Neetu R. Gupta| Oriental College of Pharmacy, Plot No.3,4,5,Sector-2 Near Sanpada Rly Station,Sanpada, Navi Mumbai, India, Aditee Mishal| Oriental College of Pharmacy, Plot No.3,4,5,Sector-2 Near Sanpada Rly Station,Sanpada, Navi Mumbai, India, Yogesh Bhosle| Oriental College of Pharmacy, Plot No.3,4,5,Sector-2 Near Sanpada Rly Station,Sanpada, Navi Mumbai, India, Supriya Shetty| Oriental College of Pharmacy, Plot No.3,4,5,Sector-2 Near Sanpada Rly Station,Sanpada, Navi Mumbai, India
Keywords
Related Articles
- EP ID EP14158
- DOI -
- Views 359
- Downloads 19
Hepatoprotective potential of Trigonella foenum graecum in deltamethrin induced albino rats
Objective: Aim of investigation focuses attention on hepatoprotective and antioxidative effect of aqueous extract of Trigonella foenum graecum (TFG) in hepatic tissue of deltamethrin fed rats. Methods: In a 45 days tre...
Spices and condiments: safer option for treatment of hyperlipidemia
Hyperlipidemia is a lipoprotein metabolic disorder characterized by high serum Low density Lipoprotein and blood cholesterol. It is a major risk factors in the development and progression of atherosclerosis that eventu...
Perceived Stress among Undergraduate Medical Students and its Determinants: A Cross-Sectional Study in a Teaching Hospital in West Bengal
Stress among medical students is a growing concern worldwide. The objectives were to assess the perceived stress, its sources and its pattern among undergraduate medical students and to find out determinants of stress am...
Implementation of time release technology in formulation development and evaluation of sustained release tablet of Lornoxicam
In present study, the attempts have been made to formulate sustained release tablets of lornoxicam by direct compression method. Based on viscosity grades different proportions of hydrophilic polymers (HPMC K4M, HPMC K...
Tissue esterases of Lamellidens corrianus (Fresh water mussel)
Polyacrylamide gel electrophoretic (PAGE) technique was used to examine the esterase pattern of Ctenidia, Hepatopancreas, Hemolymph, Intestine, Mantle. Foot of the Lamellidens corrianus. The zymograms revealed the var...