A simple validated UV spectrophotometric method for the estimation of Vilazodone hydrochloride in pure and marketed formulation
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2017, Vol 5, Issue 2
Abstract
A simple, accurate, rapid and sensitive UV Spectrophotometric method has been developed and validated for the estimation of Vilazodone Hydrochloride (VLH) in bulk as well as in marketed formulation. Vilazodone Hydrochloride is used in the treatment of major depressive disorder. It is available in the market in tablet dosage forms with strength 20mg and 40mg. The present research work involves the estimation of Vilazodone Hydrochloride using distilled water as solvent. An absorption maximum (λ max) was found to be 240 nm. It obeys the Beer’s law in the concentration range of 2-10µg/ml with a correlation coefficient value of 0.9993. The %RSD was found to be below 2.0 for repeatability, Intra and Inter-day precision studies indicated that the method was highly precise. The LOD and LOQ were found to be 0.372μg/ml and 1.126μg/ml revealed that the method was sensitive. The percentage recoveries were found to be 99.49 - 100.49 %, indicating the high accuracy of the developed method and absence of interference from the excipients present in the formulation. Validation of the proposed method has been carried out statistically as per ICH guidelines and the results were found to be satisfactory. The proposed method was found to be simple, economical, specific, accurate, precise, rugged and reproducible and hence can be applied for routine quality control analysis of Vilazodone Hydrochloride in Pharmaceutical marketed formulations.
Authors and Affiliations
G. Rudrama Devi, G. Saravanan, Mohammad Yunoos, M. V. Sai Krishna
Keywords
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