Acute toxicitty and sleep-wake eeg analysis of <i>stachtarpheta cayennensis</i> (verbenaceae) in rodents
Journal Title: African Journal of Traditional, Complementary and Alternative Medicines - Year 2005, Vol 2, Issue 3
Abstract
This study was carried out in order to establish the scientific basis of the reported ethno-medicinal use of [i]Stachytarpheta cayennensis[/i] (Verbanaceae) as sedative drug. The acute toxicity and barbituric-hypnotic test of the total aqueous (TASC), 50% ethanol (SCCR) and butanol (SCBT), ethylacetate (SCEA) fractions of dried leaves of S. cayennensis were studied in male rats and mice. The effect of systemic administration of TASC on sleep architecture in rats was also evaluated in Sprague-Dawley rats that were chronically implanted with electrodes for electroencephalogram (EEG) and electromyogram (EMG) recording. The acute toxicity test revealed no lethal effect with doses of SCCR (up to 2000 mg/kg) per oral in rats and doses of TASC (up to 1000 mg/kg and 95 mg/kg) systemically in rats and mice respectively. The extracts significantly (p
Authors and Affiliations
M. Akanmu, G. Olayiwola, O. Ukponmwan, K. Honda
Keywords
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