ADJUVANT USE OF SILYMARIN IN PATIENTS WITH HYPERTENSION AND MICROALBUMINURIA
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 10
Abstract
Microalbuminuria is an important micro-vascular complication of hypertension. It has been reported that polyphenolic compounds provide protection against the risk of cardiovascular diseases. The present study was designed to evaluate the adjuvant use of silymarin blood pressure (PB), microalbuminuria (MAU) and the lipid profile of patients with essential hypertension. A single blinded, placebo-controlled clinical trial was utilized; 80 hypertensive patients were allocated into two groups; group A, 45 patients treated with atenolol and furosemide and silymarin 420 mg/day; group B, 35 patients treated with placebo in addition to the antihypertensive drugs for 60 days. Blood pressure, lipid profile, microalbuminuria were evaluated at baseline and after 60 days. The results indicated that silymarin improves blood pressure regulation and lipid profile, in addition to decreasing microalbuminuria level compared with placebo. In Conclusion, adjuvant use of silymarin with the antihypertensive drugs (atenolol and furosemide) improves treatment of patients with essential hypertension.
Authors and Affiliations
Majeed Ahmed , Tarik Ahmad , Najeeb Basil
Keywords
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