An Analytical Study on the Various Histopathological Features of 250 Cases of Meningiomas and its Relation to the Behaviour of the Tumour
Journal Title: Indian Journal of Pathology: Research and Practice - Year 2017, Vol 6, Issue 4
Abstract
Context: Meningiomas are one of the most common primary central nervous system neoplasms. They occur most commonly in female patients being most common in the fourth and fifth decades of age. They may be of intraspinal or intracranial and extraaxial location. Aims: The aim of this study is to highlight the importance of histopathological features in analyzing the behaviour of meningiomas. Settings and Design: This is an analytical study undertaken at the department of pathology in a tertiary care hospital for a period of three years from may 2013 to june 2016. Materials and Methods: All the clinical data of the meningioma cases were obtained from the patient files in the pathology registers. The hematoxylin and eosin stained and mounted slides were retrieved and reviewed from the archives of pathology laboratory. Statistical Analysis: Statistical analysis was carried out using SPSS software version 17. Various tests used in the study were the chi square test and the T test. Results: Out of the 250 cases of meningiomas analysed in this study, 92% of the cases belonged to grade I. Features such as small cell change, hypercellularity, sheet like pattern, nuclear pleomorphism, macronucleoli, vesiculous nuclei, necrosis, hypervascularity and brain invasion were seen predominantly in higher grades ( GRADE II and III) of Meningiomas thereby proving their association with aggressive behaviour of tumour and their association was statistically significant with a P value of <0.0000001. Conclusion: Proper histopatholgical analysis is very important for the diagnosing, grading and prognostication of meningiomas.
Authors and Affiliations
Shenbagam J. M.
Keywords
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- EP ID EP471683
- DOI 10.21088/ijprp.2278.148X.6417.52
- Views 70
- Downloads 0
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