An Assessment of Ant fertility Efficacy of Ethanol Extract of Celastrus Paniculatus Seed in Male Albino Rats
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2018, Vol 13, Issue 4
Abstract
Crude ethanolic extract of Celastrus paniculans L. seeds was administered to adult male albino rats for the evaluation of its antifertility effect. Aqueous solution of the extract, when administered orally for 45 days to cover the major portion of spermatogenesis at a dose level of 250 mg/kg body weight by oral route caused significant inhibition of spermatogenesis. There was a significant decrease in essential as well as accessory reproductive organs weight (p<0.05). Decrease in cauda epididymal sperm count and motility was noted. Cytoplasmic droplets in the mid-piece of sperms were seen, which is a sign of arrival of immature spermatozoa in cauda epididymis region. Testicular histology revealed arrest of spermatogenesis at the secondary spermatocyte stage. Early stages of maturation (primary and secondary spermatocytes) showed nuclear pyknosis and vacuolization with the presence of round cells and necrotic material in the tubular lumina. Biochemical estimations of marker testicular enzymes, lactate dehydrogenase (LDH) and γ-glutamyl transpeptidase (γ-GT) showed an increase whereas sorbitol dehydrogenase (SDH) activity was significantly decreased (p<0.05). These results suggest that C. paniculatus, may induce male infertility in rats, therefore, should be evaluated further as a potential antifertility agent.
Authors and Affiliations
Madhulika Singh, G. N. Verma, Kartar Srivastava
Keywords
Related Articles
- EP ID EP395480
- DOI 10.9790/3008-1304016772
- Views 88
- Downloads 0
Formulation and Evaluation of Etoricoxib Oro Dispersable Tablets by Direct Compression Method
Oral disintegrating tablet (ODT) is defined as “A solid dosage form containing medical substances or active ingredient which disintegrates rapidly usually within a matter of seconds when placed upon the tongue”. The main...
Molecular based test for detection of cyanotoxins in the domestic drinking water tanks in Baghdad
This study was conducted to assess and analyze the common cyanobacteria in the domestic drinking water tanks in Baghdad and to see if they are potentially toxigenic.The study included isolating toxic blue green algae fro...
Dietary Restriction Initiated from Larval Stage Decreases Maximum Life Span in Drosophila melanogaster
Dietary restriction (DR) is a way of hormesis which stimulates the adaptive response in various animals. This reduces free radical formation and induces turnover of biomolecules by autophagy. In Drosophila melanogaster a...
Study Of The Role Of Septin12 Gene Expression Of Human Spermatozoa On Infertility
Septins belong to a family of polymerizing GTP-binding proteins that are required for many cellular functions, such as membrane compartmentalization, vesicular traficking, mitosis,and cytoskeletal remodeling.One family m...
Design And Characterisation Of Pulsatile Capsule Device For Flurbiprofen Using Natural Excipients
The objective of the present study was to design and characterize pulsatile capsule device for Flurbiprofen using natural excipients. The Flurbiprofen fast disintegrating tablets (FDT) were formulated using superdisinteg...