ANTI-OBESITY EFFECT OF RESVERATROL IN RATS ON HIGH FAT DIET THROUGH REGULATION OF GENE EXPRESSION OF VISCERAL WHITE ADIPOSE TISSUE
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2016, Vol 8, Issue 4
Abstract
Objective: Obesity is a chronic disease associated with serious health complications including inflammation, insulin resistance, metabolic syndrome, cardiovascular complications and several types of cancers. So this study was carried out to look for effective intervention, especially with its rising prevalence in adults and children and lack of well-tolerated therapy.Methods: Rats received high-fat diet for four months to induce obesity. Animals which had ≥30 % increase in body weight were selected in this study. Obese rats were treated for 8 w with calorie restriction (25 % food restriction of commercial chow) and/or resveratrol (30 mg/kg/day orally).Results: Obese rats demonstrated a significant elevation in the body and visceral white adipose tissue (WAT) weight, serum total cholesterol (TC), triacylglycerol (TAG) and low-density lipoprotein cholesterol (LDL-c). Visceral WAT gene expression of fatty acid synthase (FAS) significantly increased. A remarkable decrease in gene expression of peroxisome proliferator-activated receptor gamma (PPARɣ), lipoprotein lipase (LPL) and silent information regulation 2 homolog 1 (Sirt1) was recorded. The combination significantly decreased body and visceral WAT weights, TC, TAG, LDL-C and FAS mRNA expression and increased adiponectin level, the mRNA expression of PPARɣ and Sirt1as compared to individual treatments. While all treatment strategies showed a similar increase in LPL mRNA expression.Conclusion: Calorie restriction supported with resveratrol has beneficial effects in terms of reducing body weight, and appears to reverse high fat diet-induced dysregulation of expression of the genes responsible for healthy visceral WAT. Keywords: Obesity, Visceral white adipose tissue, Calorie restriction, Resveratrol.
Authors and Affiliations
Hoda Mohamed, Mervat Asker, Rawia Amin, Rana Eissa
Keywords
Related Articles
- EP ID EP577749
- DOI -
- Views 68
- Downloads 0
BIOGENIC SYNTHESIS OF SILVER NANOPARTICLES AND THEIR SYNERGISTIC EFFECT WITH ANTIBIOTICS: A STUDY AGAINST SALMONELLA SP
Objective: In recent era, medical science has turned to a variety of novel products and technologies to halt the spread of infections. The most promising and effective antimicrobial agents being embraced by modern medica...
JOB SATISFACTION OF PHARMACISTS IN ETHIOPIA: THE CASE OF HARAR TOWN
Objective: To assess job satisfaction of pharmacists in Harar town, Eastern Ethiopia.Methods: A prospective cross sectional study was conducted using the self administered questionnaire among pharmacy professionals worki...
EVALUATION OF RENAL EPITHELIAL CELL PROTEIN UNDER STRESS CONDITION
Objective: Proteins are an important component of cells which are involved in various cellular functions. Different kind of stressing conditions has different responses in the components of the protein synthesis system....
SPECTROPHOTOMETRIC METHOD FOR THE DETERMINATION OF CEFEPIME, CEFAZOLIN SODIUM AND CEFALOTHIN SODIUM IN PURE AND PHARMACEUTICAL DOSAGE FORMS BY USING NINHYDRIN
Objectives: cefazolin sodium and cefalothin sodium are the broad spectrum of antibiotics, are mainly used to control gram positive and gram negative bacterial infections. Cefepime is used to treat moderate-severe nosocom...
COMPARATIVE ANALYSIS OF ANTI-INFLAMMATORY ACTIVITY OF AQUEOUS AND METHANOLIC EXTRACTS OF C. CASSIA AND C. ZEYLANICUM IN RAW264.7, SW1353 AND PRIMARY CHONDROCYTES
Objectives: The objective of this research was to compare the anti-inflammatory activity of aqueous and methanolic extracts of C. cassia (CC) and C. zeylanicum (CZ) in mouse macrophage (RAW264.7) and human chondrosarcoma...