Antiglycation and Antioxidant Activity of Funtumia africana Root Used in the Management of Diabetes
Journal Title: Tropical Journal of Natural Product Research - Year 2018, Vol 2, Issue 5
Abstract
Received 04 April 2018 Revised 07 May 2018 Accepted 08 May 2018 Published online 10 May 2018 Funtumia africana (Benth.) Stapf (Apocynaceae) is used folklorically for the treatment of various ailments such as dysentery, urinary incontinence, burns and diabetes. The aim of the study was to evaluate F. africana root hydroethanolic extract for the ability to inhibit formation of advanced glycation end-products and reactive oxygen species. The anti-glycation activity of the extract was determined using bovine serum albumin (BSA). Total phenolic content, total antioxidant capacity, ferric reducing antioxidant power (FRAP), nitric oxide (NO), lipid peroxide and 1, 1-diphenyl-2picryl hydrazyl (DPPH) radical scavenging effects of the extract were also evaluated to determine the antioxidant activity. Result obtained, revealed that the extract significantly inhibited (P< 0.05) the formation of advanced glycation end-products (76.77%) at 100 µg/mL compared to aminoguanidine (85.76%). The total phenolic content was found to be 38.25 mg GAE/g and total antioxidant capacity 41.44 mg AAE/g of extract. DPPH, NO radical scavenging ability and FRAP of the extract were found to be concentration dependent (68.85%, 67.46% and 21.52 mg Fe2+/g respectively, at 100 µg/mL). The extract also exhibited good inhibition for lipid peroxidation in a concentration-dependent manner which was not significantly different from ascorbic acid (74.54% at 100 µg/mL). The antioxidant activity exhibited by the extract may be responsible for the observed inhibition of AGEs formation thus justifying the use of F. africana root in traditional medicine for the management of diabetes and its complications
Authors and Affiliations
Florence E. Nkemehul, Steve O. Ogbonnia, Olukemi A. Odukoya
Keywords
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- EP ID EP489559
- DOI 10.26538/tjnpr/v2i5.1
- Views 101
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