ANTIHYPERLIPIDEMIC ACTIVITY OF DIVYA METHIPACHAK AGAINST TRITON X-100 INDUCED HYPERLIPIDEMIA IN RATS
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 8
Abstract
The present study was designed to evaluate the anti-hyperlipidemic activity of Divya Methipachak a polyherbal formulation against triton induced hyperlipidemia in rats. Hyperlipidemia was induced by Triton X-100 (100 mg/kg, i.p.) and then treated with Atorvastatin (10 mg/kg, p.o) and low and high dose of Divya Methipachak (150 mg/kg and 300 mg/kg, p.o) for 7 days. The effect of treatment was analyzed by quantification of serum lipid profile, blood glucose level and histopathological analysis. The experimental results indicated all the lipid profile such as total cholesterol, Triglyceride, High density lipoprotein cholesterol, Low density lipoprotein cholesterol and the glucose level were restored significantly by all the treated groups compared to triton group. To conclude Divya Methipachak was found to be potential antihyperlipidemic agent in a dose dependent manner in alleviating abnormal conditions induced by triton.
Authors and Affiliations
Seema Setty , Jignasa Patel , Manodeep Chakraborty , Jagadish Kamath
Keywords
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