Antimicrobial activity of Ceftaroline and Ceftobiprole tested against MRSA isolates from Turkey, in 2016
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2016, Vol 11, Issue 1
Abstract
Ceftaroline and ceftobiprole are two new cephalosporin molecules on which intense studies have been made for the treatments of bacteria most of which are hospital infection factor, especially resistant gram positive cocci. Ceftaroline which has broad Gram-positive activity recently has been approved for clinical uses by the US Food and Drug Administration. Ceftobiprole has been approved for use in Canada and Switzerland. The objective of this investigation was to evaluate the activities of ceftaroline and ceftobiprole, against community-associated and hospital-associated methicillin-resistant S. aureus (MRSA). The activity of ceftaroline was measured in Kirby-Bauer disk diffusion method, broth microdilution method and E test for 60 MRSA isolates. The efficacy of ceftobiprole was measured in E test for 60 MRSA isolates. Ceftaroline MIC values of 51 (85%) isolates were determined as ≤1 µg/ml meaning of susceptible according to the criteria of CLSI/EUCAST and MIC values of 9 (15%) isolates were found as >1 µg/mL meaning of resistant by broth microdilution method. The range of ceftaroline MIC values of the isolates was found between 0.125-2 µg/ml. MIC50 and MIC90 values of all the isolates were determined as 0.50 µg/ml and 1 µg/ml for ceftaroline, respectively. Ceftobiprole MIC values of 60 (100%) isolates were determined as ≤2 µg/ml meaning of susceptible according to the criteria of EUCAST by E test. The range of ceftobiprole MIC values of the isolates was found between 0.125-2 µg/ml. MIC50 and MIC90 values of all the isolates were determined as 0.50 µg/ml and 1 µg/ml for ceftobiprole, respectively. The in vitro activities of ceftaroline and especially ceftobiprole against MRSA indicates that they should be a good therapeutic option for the treatment of infection caused by methicillin-resistant S. aureus.
Authors and Affiliations
Fulya Bayındır Bilman, Mine Turhanoğlu
Keywords
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- EP ID EP383407
- DOI 10.9790/3008-11145256
- Views 92
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