Assessment of cardiotoxicity of purine analogues in patients with lymphoproliferative neoplasms treated with chemotherapy
Journal Title: Postępy Nauk Medycznych - Year 2012, Vol 25, Issue 9
Abstract
<b>Introduction. </b>Purine analogues are chemotherapeutics widely used in treatment of lymphoproliferative neoplasms. Knowledge of their influence on cardio-vascular system is small. Contemporary methods give us an opportunity of reliable assessment of cardio-vascular system.<br><b>The aim </b>of the study was presentation of the results of our research on cardiotoxicity of purine analogues.<br><b>Material and methods.</b> 8 patients were observed in the Department of Hematology and Bone Marrow Transplantation. Age of patients ranged from 51 to 75 (median – 63 years). There were 7 men and 1 woman. They were treated with purine analogues because of chronic lymphocytic leukemia and hairy cell leukemia. Observation lasted for 3 cycles of chemotherapy. We performed physical examination with assessment of basic parameters of cardio-vascular system (blood pressure, heart rate, symptoms of cardiac failure such as: peripheral edema, lung examination, liver enlargement), ECG, ECHO (with assessment of systolic and diastolic function of left ventricle). We also performed biochemical assessments (troponin I and NT-proBNP). All assessments were performed before we started the treatment and after 3 cycles of chemotherapy.<br><b>Results.</b> We observed patients for 3 cycles of chemotherapy (3-4 months). We didn’t found any symptoms suggesting cardiotoxicity of purine analogues in physical examination, ECG, ECHO or troponin I assessments. Results of our research before and after chemotherapy didn’t differ fundamentally. 63% of patient had elevated NT-proBNP level.<br><b>Conclusions.</b> Purine analogues turned out to be safe as far as cardiotoxicity is concerned during lasting few months observation. NT-proBNP results need farther research. Because of wide indications to use of purine analogues farther research should be carried on. Methods of assessment of cardio-vascular system are easily accessible and can be performed in all centers treating neoplasms.
Authors and Affiliations
Włodzimierz Mendrek, Patrycja Zielińska, Sławomira Kyrcz-Krzemień, Ewa Szołtysik, Elżbieta Pietruszka
Keywords
Related Articles
- EP ID EP54535
- DOI -
- Views 150
- Downloads 0
Powikłania zakrzepowo-zatorowe u pacjentów z ostrymi białaczkami i chłoniakami – doświadczenia własne
<b>Wstęp.</b> Powikłania zakrzepowo-zatorowe stanowią częste zaburzenia u pacjentów z chorobami nowotworowymi zwłaszcza w przebiegu guzów litych. Ich etiologia ma charakter złożony i wieloczyn...
Przestrzeganie zaleceń medycznych przez pacjentów w wieku podeszłym
Nieprzestrzeganie zaleceń medycznych, w tym dotyczących stosowania leków, jest niezwykle częstym zjawiskiem wśród chorych w wieku podeszłym. Przyczyny tego zjawiska są złożone i obejmują aspekty psychologiczne, psychopat...
Clinical genetics of kidney cancer
Among kidney malignancies two main groups can be distinguished:1. Wilms' tumor – nephroblastoma.2. Kidney cancer – adenocarcinoma (carcinoma clarocellulare – CCRC, carcinoma papillare – PRCC, collecting duct carcinoma, c...
Primary hepatobiliary involvement in Hodgkin’s disease – a case report
Hodgkin’s lymphoma is usually a lymph node-based disease. Liver involvement is an unfavorable prognostic factor, as it generally occurs in late stage of this disease. We present a case of 48-year old patient, in whom Hod...
Zespoły mielodysplastyczne – współczesna diagnostyka, klasyfikacja i leczenie Część II: Opcje terapeutyczne w zespołach mielodysplastycznych
W ostatniej dekadzie dokonał się istotny postęp w zakresie leczenia zespołów mielodysplastycznych. Aktualnie strategie leczenia dostosowane są do zakładanych celów terapeutycznych w obrębie każdej z grup klasyfikacyjnych...