Assessment of cardiotoxicity of purine analogues in patients with lymphoproliferative neoplasms treated with chemotherapy
Journal Title: Postępy Nauk Medycznych - Year 2012, Vol 25, Issue 9
Abstract
<b>Introduction. </b>Purine analogues are chemotherapeutics widely used in treatment of lymphoproliferative neoplasms. Knowledge of their influence on cardio-vascular system is small. Contemporary methods give us an opportunity of reliable assessment of cardio-vascular system.<br><b>The aim </b>of the study was presentation of the results of our research on cardiotoxicity of purine analogues.<br><b>Material and methods.</b> 8 patients were observed in the Department of Hematology and Bone Marrow Transplantation. Age of patients ranged from 51 to 75 (median – 63 years). There were 7 men and 1 woman. They were treated with purine analogues because of chronic lymphocytic leukemia and hairy cell leukemia. Observation lasted for 3 cycles of chemotherapy. We performed physical examination with assessment of basic parameters of cardio-vascular system (blood pressure, heart rate, symptoms of cardiac failure such as: peripheral edema, lung examination, liver enlargement), ECG, ECHO (with assessment of systolic and diastolic function of left ventricle). We also performed biochemical assessments (troponin I and NT-proBNP). All assessments were performed before we started the treatment and after 3 cycles of chemotherapy.<br><b>Results.</b> We observed patients for 3 cycles of chemotherapy (3-4 months). We didn’t found any symptoms suggesting cardiotoxicity of purine analogues in physical examination, ECG, ECHO or troponin I assessments. Results of our research before and after chemotherapy didn’t differ fundamentally. 63% of patient had elevated NT-proBNP level.<br><b>Conclusions.</b> Purine analogues turned out to be safe as far as cardiotoxicity is concerned during lasting few months observation. NT-proBNP results need farther research. Because of wide indications to use of purine analogues farther research should be carried on. Methods of assessment of cardio-vascular system are easily accessible and can be performed in all centers treating neoplasms.
Authors and Affiliations
Włodzimierz Mendrek, Patrycja Zielińska, Sławomira Kyrcz-Krzemień, Ewa Szołtysik, Elżbieta Pietruszka
Keywords
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