Association between abdominal and gynoid fat mass, metabolism markers and serum androgens in obese women with polycystic ovary syndrome
Journal Title: Postępy Nauk Medycznych - Year 2012, Vol 25, Issue 11
Abstract
<b>Aim.</b> To evaluate associations between abdominal and gynoid fat, glucose and lipid metabolism markers and serum androgens in obese women with polycystic ovary syndrome (PCOS).<br><b>Material and methods.</b> In 20 women with PCOS aged 19-49 years with body mass index (BMI) 27.3-53.8 kg/m<sup>2</sup> anthropometric measurements were performed. Fasting serum glucose, lipids, insulin, leptin, LH, FSH, estradiol, androgens, SHBG, fT4 and TSH were estimated. Body composition was measured by DEXA scan.<br><b>Results</b>. All of the subjects had increased abdominal fat and were hyperandrogenic, seven of them had elevated fasting serum insulin levels, and fifteen were insulin resistant. BMI, abdominal fat and waist circumference (WC) positively correlated with triglycerides (r = 0.45, p < 0.05; r = 0.45, p < 0.05; r = 0.56, p < 0.01, respectively), insulin (r = 0.79, p < 0.001; r = 0.61, p < 0.01; r = 0.71, p < 0.01, respectively), and systolic blood pressure (r = 0.68, p < 0.001; r = 0.59, p < 0.01; r = 0.58, p < 0.01, respectively). We found a correlation between leptin levels and body weight (r = 0.68, p < 0.05), BMI (r = 0.67, p < 0.05), total fat (r = 0.62, p < 0.05) and WC (r = 0.83, p < 0.01). No direct correlation between fat mass indices and sex hormones were found. We observed a correlation between androgens and TSH: androstendione (r = 0.61, p = 0.0065) and DHEA-S (r = 0.64, p = 0.01).<br><b>Conclusions.</b> DEXA is a valuable method of body composition assessment in women with PCOS. Studied subjects had abdominal type of obesity. There was a positive correlation between abdominal obesity and cardiovascular risk factors: triglyceride and insulin levels and blood pressure. We did not prove any direct association between fatness and serum androgens but correlation between androgens and TSH was found.
Authors and Affiliations
Jarosław Kozakowski, Michał Rabijewski, Wojciech Zgliczyński
Keywords
Related Articles
- EP ID EP54326
- DOI -
- Views 149
- Downloads 0
Choroba von Hippel-Lindau
Choroba von Hippel-Lindau (VHL) jest zespołem zwiększonej genetycznej predyspozycji do nowotworów wykazującym rodowodowe cechy dziedziczenia autosomalnego dominującego. Schorzenie jest wywołane mutacjami germinalnymi gen...
Bóle stawów u osób w wieku podeszłym
Bóle stawów często dotyczą ludzi w podeszłym wieku. Ich główne przyczyny to: choroba zwyrodnieniowa, zapalne choroby tkanki łącznej (polimialgia reumatyczna, olbrzymiokomórkowe zapalenie tętnic, chondrokalcynoza, choroba...
Cardiac arrest out of hospital – etiology, prognosis, perspectives of treatment – preliminary report
91 patients post cardiac arrest in pre-hospital period were treated in Cardiac Intensive Care Unit in the years 2004-2009. The mortality rate in the whole group of patients was about 62 % There was a tendency to lower mo...
Stellate cells as a central regulator of intracellular signaling<br /> in the process of liver fibrosis
Hepatic fibrosis represents cellular response to chronic liver injury. It can lead to cirrhosis and organ failure with all their negative consequences – portal hypertension with gastrointestinal bleeding, ascites, coagul...
Zawał prawej komory serca i jego następstwa
Do zawału (MI) prawej komory (RV) dochodzi w 30-50% przypadków MI ściany dolnej lewej komory z uniesieniem ST najczęściej w przebiegu zamknięcia prawej tętnicy wieńcowej. Rozpoznanie jest trudne ze względu na złożoną bud...