ASSOCIATION OF ANGIOTENSIN-CONVERTING ENZYME GENE INSERTION/ DELETION POLYMORPHISM WITH INCREASED RISK FOR CHRONIC LYMPHOCYTIC LEUKAEMIA
Journal Title: European Journal of Biomedical and Pharmaceutical Sciences - Year 2017, Vol 4, Issue 5
Abstract
Background: Angiotensin converting enzyme (ACE) plays an important role in the stimulation bone marrow hematopoietic progenitors and umbilical cord blood cells proliferation and differentiation by converting angiotensinogen-I to its physiologically active peptide angiotensin-II which stimulates proliferation and differentiation of hematopoietic stem cells through angiotensin II type 1 receptors. Purpose: The aim of this study was to determine angiotensin converting enzyme polymorphism insertion/deletion (ACE I/D) polymorphism in Sudanese patients with chronic lymphocytic leukemia (CLL). Materials and methods: A total of 40 patients with chronic lymphocytic leukemia and 40 control subjects were enrolled in this study. Blood samples were collected from all patients in EDTA. Genomic DNA was extracted from all blood samples using salting out method.ACE I/D polymorphism as determined using polymerase chain reaction (PCR) method. Results: The results showed that I/I genotype was detected in 42.5% of cases while it was completely absent among control subjects. Conclusion: In conclusion, a significant association was found between ACE I/D polymorphism and CLL among Sudanese patients.
Authors and Affiliations
Dr. Ibrahim Khider Ibrahim
Keywords
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