ASSOCIATION OF VITAMIN D RECEPTOR GENE POLYMORPHISMS AND GESTATIONAL DIABETES IN SAUDI WOMEN
Journal Title: Journal of Experimental Biology and Agricultural Sciences - Year 2017, Vol 5, Issue 0
Abstract
Vitamin D is primarily associated with a major role in bone formation. It is also associated with onset and progniosis of diseases such as diabetes, cancer and cardiovascular diseases. In Saudi Arabia, the prevalence of DM is one of the highest reported in the world. There is accumulating evidence suggesting an association between the DM and vit D deficiency. This study was proposed to establish a possible correlation between gestational diabetes mellitus (GDM) and the polymorphisms in the vitamin D receptor (VDR) gene at the sites namely TaqI, BsmI, and ApaI. Results of this study revealed that homozygous recessive genotype tt of the TaqI site with GDM. This study will help to establish the role of VDR gene in occurrence of various subsets of DM which is a major metabolic disorder in Saudi Arabia.
Authors and Affiliations
Archana P. Iyer, Susan Lanham New, Sawsan Khoja, Maryam Al-Ghamdi
Keywords
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- EP ID EP428021
- DOI 10.18006/2017.5(3).282.287
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