Breast Cancer Regulation and Progression: A Review on Genetics and Microenvironment of Breast Cancer
Journal Title: International Journal of Medical Research Professionals - Year 2017, Vol 3, Issue 1
Abstract
Breast cancer is the most common cancer diagnosed among women. The stromal compartment of the breast includes the extracellular matrix (ECM) and stromal cells. Breast cancer is complicated by unique molecular alterations and interactions of microenvironment cells and extracellular matrix. The aim of this article is to use the literature review on (BC) risk factors, pathological and molecular subtypes. Additionally, to review the progression of (BC) at molecular signatures to address the correlation between the genotypic changes and surrounding breast stroma. The literatures covered in this review have shown that the microenvironment genetic alterations play important role on (BC) progression.
Authors and Affiliations
Zyad Musaad Alsulaiman, Abdulaziz Musaad Alsulaiman, Ali S Alharth
Keywords
Related Articles
- EP ID EP541022
- DOI 10.21276/ijmrp.2017.3.1.001
- Views 90
- Downloads 0
Conventional and Autograft Surgery for Pterygium: A Prospective Comparative Study
Background: Pterygium is a wing shaped, thick, fleshy, vascular fold of conjunctival tissue. Various techniques like irradiation, conjunctival autografting, conventional bare sclera technique, amniotic membrane transplan...
Assessment of Postoperative Pain Relief Following Use of Spinal Anesthesia and General Anesthesia for Patients Undergoing Laparoscopic Cholecystectomy: A Comparative Study
Background: General anaesthesia (GA) is the anaesthetic technique of choice for laparoscopic cholecystectomy (LC). Regional anaesthesia too (spinal/epidural/combined spinal epidural) has been reported as a sole technique...
Effects of Tranexamic Acid on Perioperative Blood Loss Associated with Total Knee Arthroplasty: A Randomized Double Blinded Prospective Study
Introduction: Total knee arthroplasty is usually associated with minimal intra-operative, but extensive postoperative blood loss, also because of the application of pneumatic tourniquet application there are theoretical...
Multiple Myeloma in Relation to Different Geographical Distribution, Socioeconomic Status and Level of Education: A Hospital Based Study at a Tertiary Level Hospital, Guwahati, Assam
Background: The risk factors for multiple myeloma (MM) are not conclusive, because the cause of MM is not clearly known. Researchers believe that MM is most likely the result of many risk factors acting together. Despite...
Evaluation of Clinico-Radiological Association with CT Guided FNAC of Various Lung Lesions: A Hospital Based Study
Introduction: Fine-needle aspiration cytology (FNAC) is a basic, fast, trustworthy strategy for the diagnosis of lung lesions, specially with the guide of computed axial tomography (CAT) scan. The present study was plann...