Calponin 1 Serum Level A Biological Marker for Preterm Labor Predictability
Journal Title: Interventions in Gynaecology and Women’s Healthcare - Year 2018, Vol 2, Issue 4
Abstract
Preterm birth is featured and defined as delivery before 37 gestational weeks global occurrence in 15 million neonates and represents around 11% of all living births. The threatened preterm delivery has an incidence around two to three times greater between 24 and 34 gestational weeks than the 34-37 gestational weeks. The bulk of cases with preterm delivery clinical presentation before 32 gestational weeks are referred to a tertiary hospital and managed with tocolytic agents e.g, MgSO4 and lung maturity enhancing agent such as corticosteroids. On the other hand, around 80% of these patients would not give birth within 1 week after hospital admission, and 50 percent of those gestations deliver at term. For that reason, several patients are needlessly referred and exposed to the possible side effects of tocolytic drugs and corticosteroids for both mother and fetus [1]. The usefulness of forecasting those patients that will not give birth in the short period of time (within 1 week) is necessary consecutively to avoid over management and reduce the costs of needless admissions and management protocol usage. Alternatively, the precise recognition of this form of symptomatic cases with preterm delivery symptoms aids to uncover those that require emergency interventional mode of management and referral to a tertiary level of care hospital for the aim to reduce the possible perinatal risks when preterm birth occurs [2]. Various researchers investigated biological markers and clinical approaches for predictability of preterm birth; yet, it still a difficult issue to evaluate this prediction in cases with threatened preterm labor. Prior research studies displayed that cervical length dimension measuring and fetal fibronectin testing could aid to identify patients that would not clinically benefit from tocolytic agent implementation. Numerous research systematic reviews priorly performed have displayed and revealed that the cervical length dimension more than 25mm and a cut off value of 0.050mg/ mL of fetal fibronectin are valuable as negative predictive indices for preterm delivery within 1 week [3]. Various researchers mentioned that calponin -1 protein, an actin filament-linked regulatory type of protein with a molecular weight of 34-37 kDa (292-330 amino acids), acting at molecular and cellular level as an inhibitor of actin-activated myosin ATPase in smooth muscles and non-muscular type of cells. Smooth muscle contractions are integrated in action chiefly by the reversible phosphorylation action of myosin light chain, being triggered by a rise in sarcoplasmic-free calcium cellular concentration [4]. Alternatively, these contractions could be organized and ordered by different signal transduction molecular and cellular action pathways, e.g the thin filament-linked calponin 1 protein. Our research considered that calponin 1 protein, which is featured as a smooth muscle troponin-like form of protein, could clinically serve as a biological marker for precise predictability of the time of birth in threatened preterm delivery case scenario. This research approached consideration and hypothesis is based mainly on the fact that calponin 1, protein is the most copious and definite protein in smooth muscle tissue. In addition, all through the second and third gestational trimesters, the uterus contain the largest quantity of smooth muscle and calponin protein [5]. Additionally, uterine contractions causing the delivery process to occur Could cause myometrial damage that could lead to raised calponin 1 levels in maternal serum [6].
Authors and Affiliations
Mohamed Ibrahim Taema, Rania Ali Ammar Abd El Hakim
Keywords
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- EP ID EP574531
- DOI 10.32474/IGWHC.2018.02.000141
- Views 78
- Downloads 0
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