CHANGING TREND OF ANTIBIOTIC SUSCEPTIBILITY PATTERN OF COMMON GRAM NEGATIVE BACILLI ISOLATED FROM MEDICAL INTENSIVE CARE UNIT OF TERTIARY CARE HOSPITAL AHMEDABAD, GUJARAT, INDIA
Journal Title: Journal of Drug Discovery and Therapeutics - Year 2013, Vol 1, Issue 4
Abstract
Introduction: Resistance among Gram-negative bacilli antimicrobial remains a significant problem for patients in the intensive care unit (ICU). Multi-resistant gram-negative bacilli are important pathogens in ICUs, causing high rate of mortality. The purpose of this study was to investigate change in antimicrobial resistance patterns among common Gram-negative bacilli isolated from Medical ICU patients.Method and Materials: In duration of two years (2011, 2012) all Gram negative bacilli isolated from different clinical specimens from MICU were evaluated for sensitivity patterns by Kirby-Bauer disc diffusion method.Results: The most frequently isolated organisms were Acinetobacter baumannii, Pseudomonas aeruginosa, Escherichia coli and Klebsiella sp.. Antibiotic susceptibility patterns significantly declined in those organisms, A baumannii showed decreased susceptibility to carbapenem (4.2% to 56.2% resistant), ampicillin sulbactam (48.1 to 62.5% resistant)and netilmycin (68.5 to 87.7% resistant).Pseudomonas aeruginosa also showed decreased susceptibility for carbapenem (6.2 % to 43.9% resistant),netilmycin and for quinolones(II)(resistant up to 65.1 & 76.2% respectively).Same way susceptibility to commonly use antibiotics for E.coli and Klebsiella sp. were also decreased.Conclusion: Antimicrobial resistance is an emerging problem in MICU. Continuous monitoring of antimicrobial susceptibility and strict adherence to infection prevention guidelines are essential to eliminate major outbreaks in the future.
Authors and Affiliations
Dr. Parimal H. Patel*| Tutor, Department of Microbiology, Smt. NHL Municipal Medical College Ahmedabad, India-380006, Dr. Sanjay Rathod| Associate Professor, Department of Microbiology, Smt. NHL Municipal Medical College Ahmedabad, India-380006, Dr. Bimal Chauhan| Assistant Professor, Department of Microbiology, Smt. NHL Municipal Medical College Ahmedabad, India-380006, Dr. Hetal Rathod| 1st Year Resident, Department of Microbiology, Smt. NHL Municipal Medical College Ahmedabad, India-380006, Dr. Jayshree Pethani| Associate Professor, Department of Microbiology, Smt. NHL Municipal Medical College Ahmedabad, India-380006, Dr. Parul Shah| Professor & Head, Department of Microbiology, Smt. NHL Municipal Medical College Ahmedabad, India-380006
Keywords
Related Articles
- EP ID EP1370
- DOI -
- Views 524
- Downloads 40
A review on recent advances of oral mouth dissolving tablet
Mouth dissolving tablets are disintegrating and dissolve rapidly in mouth cavity without need of water. Many tablets are design to dissolve in mouth fast in few second and other true fast dissolving tablets. Oral mouth d...
Acute toxicity and histo-pathological studies of liver of ethanolic extract of roots of cissampelos pareira in animals model
Cissampelos pareira Linn. is a very variable, lofty, slender, dioecious, perennial, climber commonly distributed throughout topical and sub topical India, ascending up to an altitude of c 2,000m. The plant is very common...
Hepatoprotective models and screening methods: a review
Liver, the largest organ in the body is being evolved to maintain the body’s internal milieu and also protect itself from the challenges it faces during its implementation. It is a essential organ having assorted functio...
FORMULATION AND DEVELOPMENT OF ENTERIC COATED ORNIDAZOLE TABLET FOR COLON TARGETED DRUG DELIVERY SYSTEM
Lactose-based placebo tablets were prepared and coated using various combinations of Eudragit L100 and Eudragit S100, by spraying from aqueous systems. The Eudragit L100 Eudragit S100 combinations (w/w) studied were 1:0,...
A concrete and ethical reverences for noninvasive prenatal diagnosis of fetal aneuploidy present in maternal blood
Down's syndrome could be diagnosed before conception (prenatally) or after life commencement (postnatally). Throughout pregnancy, there are two sorts of tests that could be carried out to search for Down's syndrome - a s...