Characterization of Ceiba petandra and Lannea kerstingii Stem Bark Extract Creams
Journal Title: Journal of Pharmaceutical & Health Sciences - Year 2017, Vol 5, Issue 1
Abstract
A study on physicochemical characteristics of Ceiba petandra and Lannea kerstingii stem bark extracts cream, being developed for the treatment of topical dermatophyte infections, has been carried out to assure its safety, effectiveness, and stability during storage and usage. The stem barks of Ceiba petandra and Lannea kerstingii were extracted with methanol and ethyl acetate respectively. The obtained extracts and their combinations were formulated into creams using modified Aqueous Cream BP base at concentrations ranging from 0.4 to 3.2%w/w. Physical and chemical characteristics of the creams such as stability, viscosity, pH, diffusion, irritancy and elegance were evaluated. Ketoconazole cream was used as the reference product. Creams prepared with each extract alone exhibited favorable characteristics in terms of spreadability, non-irritancy, stability, and diffusivity. Creams formulated with Ceiba petandra were most stable with pH ranges of 6.21 to 7.13. Those formulated with Lannea kerstingii were more acidic. Creams formulated with the combinations of the two extracts exhibited some levels of incompatibility, which increased with increasing extract concentrations. The rate of diffusion of the extracts from cream base increased with time and was generally more at 37 ºC as compared to that at 25 ºC. Cream formulations of the stem bark extracts of Ceiba petandra and Lannea kerstingii, but not their combinations using modified Aqueous Cream (BP), possess satisfactory physicochemical characteristics.
Authors and Affiliations
Olusola Isaac Aremu, Adeola Tawakalitu Kola-Mustapha, Taiye Hameedat Ayotunde
Keywords
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