Characterization of prescription and OTC formulations of vidarabine cream
Journal Title: World Journal of Pharmaceutical Sciences - Year 2017, Vol 5, Issue 1
Abstract
The aim of this study, to assess the uniformity of content, viscosity, spreadability, near-infrared absorption spectroscopy and water content of vidarabine cream (Ara-A: bland name, Ara-B: generic and Ara-C: Over the Counter). Moreover, this study assessed the physicochemical properties of the creams. The Uniformity test indicated that the VDN content was uniform and equivalence was observed. As results of viscosity, Ara-B differed from those in Ara-A and Ara-C. The yield value was calculated based on measured flattening and was 1109.8 dynes/cm2 for Ara-A, 527.7 dynes/cm2 for Ara-B, 1200.1 dynes/cm2 for Ara-C. Measurement of water content revealed that Ara-A, and -C had water content of around 56.3%, Ara-B had water content of 59.9%. NIR absorption spectroscopy revealed that Ara-B had the highest absorption peak due to hydroxyl groups, followed by Ara-A, then -C. In order to evaluate the feel on the skin, friction generated by Ara-A and-C was around 90 N, Ara-B was 54.4 N. The drug spread is good about the skin friction, spreadability might be affecting the human sensory.
Authors and Affiliations
Dr. Yutaka Inoue
Keywords
Related Articles
- EP ID EP312260
- DOI -
- Views 101
- Downloads 0
Role of mifepristone in conservative management of fibroid uterus
Women aged between 30's and 40's years facing several gynaecological problems. Uterine leiomyomas or fibroids are common gynaecological problems among women with a variable prevalence. The main symptoms are accompanied w...
Comparing gangion cell complex and retinal nerve fibre layer for the early diagnosis of glaucoma
Context: With the newertechnologies like Optical Coherence Tomography(OCT), it’s time to rethink whether Retinal Nerve Fibre Layer (RNFL) thickness is the earliest tool for glaucoma detection or Ganglion Cell Complex (GC...
Word making by linguistics of alphabets reflects on elemental catenation of periodic table to produce creativity
Renowned academician Prof. Dr. Dhrubo Jyoti Sen has completed his B.Sc. (Hons) (1987) from Patna University, Patna & B.Pharm. (Hons) (1992), M.Pharm. (1994) & Ph.D. (2001) from Jadavpur University, Calcutta and now worki...
Use of alizarin red S as a chromogenic agent for spectrophotometric determination of loratadine in pharmaceutical formulations
The study involved two simple, rapid, selective and cost-effective spectrophotometric methods for the determination of loratadine in pharmaceutical formulations. Method A was based on the formation of yellow coloured ion...
In-vitro pharmacological applications of pigment producing halophilic microorganism from the marine region of India
In the present study, two pigment producing promising strains were identified and characterized based on the biochemical properties from the halophilic environment. Based on the biochemical and physiological characterist...