CHEMOPROTECTIVE EFFECT OF EDIBLE GASTROPOD, XANCUS PYRUM AND ITS USEFULNESS IN THE AMELIORATION OF CISPLATIN-INDUCED TOXICITY
Journal Title: Asian Journal of Pharamceutical and Clinical Research - Year 2017, Vol 10, Issue 12
Abstract
  Objective: The main purpose of this study was to evaluate chemoprotective activities of methanolic extracts of an edible gastropod (Xancus pyrum) in cisplatin-induced immunosuppressed mice.Methods: Cisplatin (100 mg/kg, intraperitoneally [IP]) induced immunosuppressed mice were treated with a methanolic extract of X. pyrum (0.5 mg/dose/animal/IP) for a period of 10 days. The effect of the extract on lymphoid organ weight, bone marrow cellularity (BMC), alpha esterase activity, and on enzyme levels such as serum glutamic oxaloacetic transaminase, serum glutamic pyruvic transaminase, urea, and creatinine was estimated to identify the chemoprotective activity of X. pyrum.Results: Administration of X. pyrum extract in cisplatin-treated mice, found to enhance the BMC and alpha-esterase positive cells, which were drastically reduced in cisplatin alone treated control animals suggests that cisplatin-induced myelosuppression was reversed or inhibited by X. pyrum extract administration possibly through its chemoprotective activity.Conclusion: Cisplatin and its metabolites can bind to DNA, causing damage that may result in chromosome breaks, micronucleus formation and cell death. Administration of X. pyrum extract in cisplatin-treated mice, found to enhance the BMC and alpha-esterase positive cells, which were drastically reduced in cisplatin alone treated control animals suggests that cisplatin-induced myelosuppression was reversed or inhibited by X. pyrum extract administration possibly through its chemoprotective activity.
Authors and Affiliations
Bindhu Jayaprakash, Emilin Renitta
DESIGN, PREPARATION, AND EVALUATION OF SELF-MICROEMULSIFYING DRUG DELIVERY SYSTEM OF BAMBUTEROL HYDROCHLORIDE
Objective: The self-micro-emulsifying drug delivery system (SMEDDS) of bambuterol hydrochloride was designed, prepared, and evaluated to overcome the problem of poor bioavailability.Methods: The designing of the formulat...
Research Article LEAVES EXTRACT-BASED BIOGENIC SYNTHESIS OF CUPRIC OXIDE NANOPARTICLES, CHARACTERIZATIONS, AND ANTIMICROBIAL ACTIVITY
Objectives: Tulsi (Ocimum tenuiflorum) leaves extract-based synthesis of cupric oxide nanoparticles (CuONPs), characterizations, and antimicrobial activity. Methods: The small cut leaves were washed with double distille...
DESIGN AND EVALUATION OF SELF-NANOEMULSIFYING DRUG DELIVERY SYSTEMS OF MANIDIPINE FOR ENHANCEMENT OF SOLUBILITY
Objective: The present work is aimed at developing liquid self-nanoemulsifying drug delivery system (liquid-SNEDDS) of manidipine. Methods: The manidipine SNEDDS is formulated with excipients comprising Capmul MCM as oi...
STUDY OF PRESCRIBING PATTERN AND USE OF ANTIBIOTIC IN THE MANAGEMENT OF WOUND INFECTION
Objective: The main objective of the study is to estimate the demographic details of patients with various wound infection and to observe the variousorganism causing infections and also to analyze the prescribing pattern...
IN SILICO DOCKING APPROACH FOR ANTIATHEROSCLEROTIC ACTIVITY OF PHYTOCONSTITUENTS OF CORCHORUS AESTUANS AND ADMET PREDICTION
 Objective: Atherosclerosis is a persistent inflammatory condition within the arterial wall characterized by alterations in lipid metabolism. LiverX alpha receptor is highly expressed in liver could regulate the cholest...