Classification and Mechanism of Action of Anti-Parasitic Drugs: A Review Article
Journal Title: International Journal of Health & Medical Research - Year 2025, Vol 4, Issue 01
Abstract
The action of antiparasitic drugs is critical in the treatment of infections caused by parasites and that have devastating effects on millions of individuals worldwide. This paper consolidates different research findings on the classification and mechanisms of action of these drugs, highlighting new therapies and natural products. In particular, this special class of heterocyclic compounds, known as Benzimidazoles, has garnered a wide interest in medicinal chemistry due to their broad pharmacological activities. It recognizes the important contribution normally made by these drugs in the treatment of a wide range of different diseases, including cancer, bacterial infection, and parasitic disease. Drug-resistant parasites are now increasingly prevalent and have greatly impeded the management of parasitic infections; thus, there is an increasing demand for new therapeutic approaches. Anti-parasitic metallodrugs have emerged as another auspicious mode of intervention that carefully exploits the unique chemical features of metal ions and their complexes to affect the biological pathways important for the survival of the parasite. In this paper, we will draw up a range of knowledge gaps identified up-to-date and propose future research directions that would enhance the understanding and, what is more important, the efficiency of anti-parasitic therapies.
Authors and Affiliations
Bareq A. Al-lateef, Hawraa Ahmed Ali, Inas Abbass Kheiruralla , Ali A. Al-fahham,
Keywords
Related Articles
- EP ID EP761556
- DOI 10.58806/ijhmr.2025.v4i1n01
- Views 11
- Downloads 0
Occlusal Appliance Therapy for Temporomandibular Joint Disorders: Mechanisms, Efficacy, and Limitations
Disorders of the temporomandibular joint (TMJ) are chronic conditions that involve pain, muscle spasm, and dysfunction of the joint and surrounding structures. Occlusal appliances have come to be regarded as essential to...
A Comprehensive Review on Chalcones: Preparation Methods, Reactions and Their Biological Activities
Despite their discovery in the early nineteenth century, chalcone compounds have evolved and played a significant role in medical and industrial applications. The most important feature of these compounds is that they co...
In Silico Study, Synthesis and Evaluation of Cytotoxic Activity of New Sulfonamide-Isatin Derivatives as Carbonic Anhydrase Enzyme Inhibitors
Aim: Design, molecular docking, synthesis, and evaluation of cytotoxic activity of new compounds I, II, III, and IV that have isatin-sulfonamide derivatives. Materials and Methods: for chemical synthesis, chemical compo...
Surgical Interventions in Children with Congenital Heart Disease: A Review Article
Congenital malformation of the heart stands as one of the most common congenital anomalies at birth. However, with the advancement in cardiovascular medicine and surgery, a majority of the children can nowadays still liv...
Evaluation of the Biosafety Training Developed in the Primary Health Care Clinical Laboratory
Introduction: Biosafety constitutes a strategic approach to analyze, evaluate and manage, as well as to propose a system of actions to eradicate risks. Materials and methods: A prospective, analytical, observational st...