Clinical aspects of assessment of endothelial function.
Journal Title: Pharmacological Reports - Year 2006, Vol 58, Issue 0
Abstract
Prevention and treatment of atherosclerosis is an important priority. Measurement of endothelial function has been reported as a useful tool for atherosclerosis research. Endothelium appear to integrate the injury of commonly known risk factors and others, genetic and environmental as yet undiscovered. The assessment of endothelium-dependent vasodilation has emerged as indicator of endothelial health. Invasive methods examine coronary or brachial artery vasomotion in response to infusion of acetylcholine. Noninvasive ultrasound assessment of flow-mediated vasodilation (FMD) of peripheral artery is more often used. However, despite its wide-spread use, there are technical and interpretive limitations of this technique. Recent studies have shown that the severity of endothelial dysfunction relates to cardiovascular risk. Endothelial function might be also used to monitor the effectiveness of risk reduction therapy. This article will review the growing literature in an effort to evaluate methods of assessment of endothelial function and its clinical utility.
Authors and Affiliations
Jarosław Kasprzak, Magdalena Kłosińska
Keywords
Related Articles
- EP ID EP159879
- DOI -
- Views 87
- Downloads 0
Effect of apigenin, kaempferol and resveratrol on the expression of interleukin-1betaand tumor necrosis factor-alpha genes in J774.2 macrophages.
Flavonoids have been reported to bring benefits in lowering inflammation,oxidative stress and exert positive effects in cancer and cardiovascular and chronic inflammatory diseases.Apigenin, kaempferol and resveratrol pre...
Mechanisms of [Ca(2+)]i elevation following P2X receptor activation in the guinea-pig small mesenteric artery myocytes.
Background: There is growing evidence suggesting involvement of L-type voltage-gated Ca(2+) channels (VGCCs) in purinergic signaling mechanisms. However, detailed interplay between VGCCs and P2X receptors in intracellula...
Modulatory effect of high saturated fat diet-induced metabolic disturbances on angiogenic response in hepatocyte RXRα knockout mice.
Metabolic syndrome and diabetes lead to pathological angiogenesis and angiopathy. Metabolic disturbances occur as an effect of genetic and environmental interaction. Hyperleptinemia accompanies obesity and leptin is a po...
Paracetamol treatment increases telomerase activity in rat embryonic liver cells.
Although paracetamol is known to have a damaging effect, this pharmaceutical is widely applied to pregnant and lactating women. Despite substantial progress in our understanding of its hepatotoxicity, some mechanisms, pa...
Long-term use of low-dose spironolactone in spontaneously hypertensive rats: Effects on left ventricular hypertrophy and stiffness.
The aim of the present study was to evaluate the effect of low-dose spironolactone initiated during the early stages of hypertension development and to assess the effects of chronic pressure overload on ventricular remod...