CLINICAL STUDY OF ASSOCIATION BETWEEN THE SERUM SODIUM LEVEL AND SEVERITY OF COMPLICATIONS IN LIVER CIRRHOSIS AT KANYAKUMARI GOVERNMENT MEDICAL COLLEGE.
Journal Title: International Journal of Advanced Research (IJAR) - Year 2018, Vol 6, Issue 10
Abstract
Background: Cirrhosis is defined histopathologically and has variety of clinical manifestations and complications, some of which can be life-threatening..Dilutionalhyponatremia associated with liver cirrhosis is caused by impaired free water clearance . The aim of this study was to evaluate the association between the serum sodium level and the severity of complications in liver cirrhosis . Methods:This study was conducted in Kanyakumari Government Medical College in the department of general medicine . 200 patients were included in the study over a period from August 2017 ? August 2018 for a period of 1 year . Data of inpatients with cirrhotic complications were collected retrospectively . The serum sodium level and severity of complications of 200 inpatients were analysed. Results:The prevalence of dilutionalhyponatremia, classified as serum sodium concentrations of >135 mmol/L, 131-135 mmol/L, and ≤130 mmol/L, were 44%, 24%, and 32%, respectively. The serum sodium level was strongly associated with the severity of liver function impairment as assessed by Child-Pugh and MELD scores (p<0.0001). Even a mild hyponatremia with a serum sodium concentration of 131-135 mmol/L was associated with severe complications. Conclusion: Hyponatremia is more common in liver cirrhosis and low serum sodium levels are associated with complications such as hepatic encephalopathy ,hepatorenal syndrome , spontaneous bacterial peritonitis and GI bleeding . Lower serum sodium levels were associated with increased MELD CPS score and mortality indicating the inverse relationship between serum sodium levels and severity of the disease.
Authors and Affiliations
Amalan Christudhas V, Ilakkiya Venu, Suhas Raj Sivakumar, Silambarasan .
Keywords
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- EP ID EP409574
- DOI 10.21474/IJAR01/7820
- Views 63
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