Colorimetric and Kinetic method for determination of Dapsone in bulk and pharmaceutical preparations
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2015, Vol 3, Issue 1
Abstract
Simple, rapid, accurate, and sensitive method for determination of dapsone in bulk and pharmaceutical preparation the method was based on reaction of 4-nitro phenol with dapsone in presence of acid medium and heating, forming yellow complex, having absorption maximum at 460 nm. Beer’s law was obeyed in the concentration range of (3-50) µg/ml with correlation coefficient equal to 0.9999 and relative standard deviation (RSD) less than 1.0%, the recovery was found to 99.99%. The method can be applied successfully to quality control laboratories and can be applied to pharmaceutical preparation.
Authors and Affiliations
Safaa Mohamed Abdel Alhamid
Keywords
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